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The anti-stress effect of chewing to stress disease

Research Project

Project/Area Number 23792453
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Orthodontic/Pediatric dentistry
Research InstitutionKanagawa Dental College

Principal Investigator

MIYAKE Shinjiro  神奈川歯科大学, 歯学部, 助教 (40454152)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywordsストレス / 咀嚼器官 / 空間記憶 / GR 受容体 / PTSD
Research Abstract

The present study aims clarifying the relativity of the dental apparatus and the brain function, and the use of the improvement of the oral function to prevent and to treat to the stress disease. It reported on the thesis from research results for which Morris water maze used that the hippocampus space memory to deteriorate by the stress by chewing was recovered at this study period. The anti-stress effect to the stress decrease of similar chew organ activation was confirmed by behavior experiment and an electric physiology by using the model rat of PTSD who was the representative of the saucer stress disease.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (18 results)

All 2013 2012 2011 Other

All Journal Article (6 results) (of which Peer Reviewed: 6 results) Presentation (12 results)

  • [Journal Article] Chewing ameliorates stress-induced suppression of spatial memory by increasing glucocorticoid receptor expression in the hippocampus.2012

    • Author(s)
      Miyake S, Yoshikawa G, Yamada K, Sasaguri K, Yamamoto T, Onozuka M, Sato S
    • Journal Title

      Brain Research

      Volume: 1446 Pages: 34-39

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Lee MC: Stress and chewing affect blood flow and oxygen levels in the rat brain2012

    • Author(s)
      Miyake S, Wada-Takahashi S, Honda H,Takahashi SS, Sasaguri K, Sato S
    • Journal Title

      Archives of Oral Biology

      Volume: 57(11) Pages: 1491-7

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Combination of chewing and stress up-regulates hippocampal glucocorticoid receptor in contrast to the increase of mineralocorticoid receptor under stress only2012

    • Author(s)
      Sasaguri K, Yoshikawa G, Yamada K, Miyake S, Kubo KY, Yamamoto T.
    • Journal Title

      Neuroscience Letters. Jun 21

      Volume: 519(1) Pages: 20-5

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Stress and chewing affect blood flow and oxygen levels in the rat brain.2012

    • Author(s)
      Miyake S., Wada-Takahashi S., Honda H., Takahashi SS., Sasaguri K., Sato S., Lee M-C.
    • Journal Title

      Archives of Oral Biology

      Volume: 57(11) Issue: 11 Pages: 1491-1497

    • DOI

      10.1016/j.archoralbio.2012.06.008

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Combination of chewing and stress up-regulates hippocampal receptor in contrast to the increase of mineralocorticoid recepor under stress only.2012

    • Author(s)
      Sasaguri Kenichi
    • Journal Title

      Neuroscience Letters.

      Volume: Jun 21; 519 (1) Issue: 1 Pages: 20-25

    • DOI

      10.1016/j.neulet.2012.04.080

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Chewing ameliorates stress-induced suppression of spacial memory by increasing glucocorticoid receptor expression in the hippocampus2012

    • Author(s)
      Shinjiro Miyake, Gota Yoshikawa, Kentaro Yamada, Ken-ichi Sasaguri, Toshiharu Yamamoto, Minoru Onozuka, Sadao Sato.
    • Journal Title

      BRAIN RESEARCH

      Volume: 1446 Pages: 34-39

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] 咀嚼器官活性化によるストレス減弱効果を活用した災害時のストレス疾患予防・改善への取り組み2013

    • Author(s)
      三宅真次郎,小泉創、笹栗健一
    • Organizer
      第一回災害医療歯科学研究報告会
    • Place of Presentation
      神奈川
    • Year and Date
      2013-03-31
    • Related Report
      2012 Final Research Report
  • [Presentation] 咀嚼によるストレス性心不全の予防効果2013

    • Author(s)
      小泉創、南沢享、三宅真次郎、笹栗健一、小野弓絵
    • Organizer
      第90回日本生理学会大会
    • Place of Presentation
      東京
    • Year and Date
      2013-03-27
    • Related Report
      2012 Final Research Report
  • [Presentation] 咀嚼によるストレス緩和に心不全抑制効果2013

    • Author(s)
      小泉創、三宅真次郎、小野弓絵、南沢享、笹栗健一、秋本進
    • Organizer
      神奈川歯科大学学会・例会
    • Place of Presentation
      神奈川
    • Year and Date
      2013-01-10
    • Related Report
      2012 Final Research Report
  • [Presentation] 咀嚼刺激によるストレス性不整脈の予防効果2012

    • Author(s)
      小泉創、南沢享、笹栗健一、三宅真次郎、小野弓絵
    • Organizer
      第65回日本自律神経学会総会
    • Place of Presentation
      東京
    • Year and Date
      2012-10-25
    • Related Report
      2012 Final Research Report
  • [Presentation] 咀嚼によるストレス緩和は不整脈の発生を防ぐ2012

    • Author(s)
      小泉創、三宅真次郎、山田健太朗、笹栗健一
    • Organizer
      第54回歯科基礎医学学会学術・総会
    • Place of Presentation
      福島
    • Year and Date
      2012-09-15
    • Related Report
      2012 Final Research Report
  • [Presentation] 瞳孔反応を指標とした下顎位の変化が自律神経系に与える影響2011

    • Author(s)
      三宅真次郎、小泉創、小手川泰枝、笹栗健一、原直人、秋本進
    • Organizer
      第70回日本矯正歯科学会大会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-10-19
    • Related Report
      2012 Final Research Report
  • [Presentation] 咀嚼によるストレス緩和は不整脈の発生を防ぐ

    • Author(s)
      小泉 創
    • Organizer
      第54回歯科基礎医学学会
    • Place of Presentation
      福島
    • Related Report
      2012 Annual Research Report
  • [Presentation] 咀嚼刺激によるストレス性不整脈の予防効果

    • Author(s)
      小泉 創
    • Organizer
      第65回自律神経学会総会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] 咀嚼によるストレス緩和に心不全抑制効果

    • Author(s)
      小泉 創
    • Organizer
      神奈川歯科大学学会・例会
    • Place of Presentation
      神奈川
    • Related Report
      2012 Annual Research Report
  • [Presentation] 咀嚼によるストレス性心不全の予防効果

    • Author(s)
      小泉 創
    • Organizer
      第90回日本生理学会大会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] 咀嚼器官活性化によるストレス減弱効果を活用した災害時のストレス疾患予防・改善への取り組みVol. 1

    • Author(s)
      三宅 真次郎
    • Organizer
      第1回災害医療歯科学研究報告会
    • Place of Presentation
      神奈川
    • Related Report
      2012 Annual Research Report
  • [Presentation] 咀嚼器官活性化によるストレス減弱効果を活用した災害時のストレス疾患予防・改善への取り組みVol. 2

    • Author(s)
      小泉 創
    • Organizer
      第1回災害医療歯科学研究報告会
    • Place of Presentation
      神奈川
    • Related Report
      2012 Annual Research Report

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Published: 2011-08-05   Modified: 2019-07-29  

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