Analysis of osteoclastogenesis regulated by orthodontic force
Project/Area Number |
23792455
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Orthodontic/Pediatric dentistry
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Research Institution | Matsumoto Dental University |
Principal Investigator |
ARAI Atsushi 松本歯科大学, 歯学部, 助教 (00532772)
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Project Period (FY) |
2011 – 2012
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Project Status |
Completed (Fiscal Year 2012)
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Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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Keywords | 破骨細胞 / 破骨細胞前駆細胞 / RANK / RANKL / c-Fos / M-CSF / c-fmsマクロファージ / 矯正力 / 歯の移動 / c-fms |
Research Abstract |
We previously reported that osteoclast precursors were detected as RANK-positive cells in bone tissues. RANK-positive cells were observed in bone tissues in RANKL-/- mice, but not in c-Fos-/- mice. c-Fos, but not RANKL, is required for the up-regulation of RANK in osteoclast precursors. Then, we analyzed the mechanism of c-Fos-mediated up-regulation of RANK in osteoclast precursors. Our results suggest that c-Fos plays essential roles not only in RANKL-induced formation of osteoclasts but also in M-CSF-induced formation of osteoclast precursors.
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Report
(3 results)
Research Products
(12 results)
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[Journal Article] Lineage-Committed Osteoclast Precursors Circulate in Blood and Settle Down Into Bone2011
Author(s)
Muto, A, Mizoguchi, T, Udagawa, N., Ito, S, Kawahara, I, Abiko, Y, Arai, A., Harada, S., Kobayashi, Y., Nakamichi, Y, Penninger, JM, Noguchi, T, Takahashi, N.
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Journal Title
Journal of Bone and Mineral Research
Volume: 26
Issue: 12
Pages: 2978-2990
DOI
Related Report
Peer Reviewed
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