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The recovery mechanism and cell injury from orthodontic treatment with promoter of transplanted bone marrow-derived cell migration into periodontal tissues

Research Project

Project/Area Number 23792456
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Orthodontic/Pediatric dentistry
Research InstitutionMatsumoto Dental University

Principal Investigator

MURAOKA Rina  松本歯科大学, 歯学部, 助教 (20549430)

Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords骨髄幹細胞 / 歯根膜 / 歯周組織 / 歯科矯正学 / 治療 / 修復 / 再生 / リモデリング / 細胞分化 / 組織修復
Research Abstract

In this study, we aimed that the elucidation of the molecular regulation mechanism of recovery and cytotoxicity of periodontal tissue by orthodontic mechanical stress, and to clarify the development of the control method, the full particulars of the function and dynamics of bone marrow-derived cell.
Using the mouse that performed the bone marrow-derived cell transplantation, and were elucidated the involvement of bone marrow-derived cell in the surrounding bone and tissue study of cell injury to receive the periodontal ligament fibroblasts in particular periodontal ligament tissue loaded with orthodontic academic ability in mouse molars. Bone marrow stem cells were shown to engraft in a thriving site remodeling mostly in periodontal tissue showed experimentally that this phenomenon is associated with the dense and cells of the nervous system.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (40 results)

All 2013 2012 2011 2010 Other

All Journal Article (12 results) (of which Peer Reviewed: 12 results) Presentation (25 results) Book (3 results)

  • [Journal Article] Promotion of Transplanted Bone Marrow-derived Cell Migration into the Periodontal Tissues due to Orthodontic Mechanical Stress2013

    • Author(s)
      Mihoko Tomida, Rina Muraoka,他6名
    • Journal Title

      Int J Med Sci.

      Volume: 10(10) Pages: 1321-1326

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Promotion of Transplanted Bone Marrow-derived Cell Migration into the Periodontal Tissues due to Orthodontic Mechanical Stress2013

    • Author(s)
      Tomida M, Tsujigiwa H, Nakano K, Muraoka R, Nakamura T, Okafuji N, Nagatsuka H, Kawakami T
    • Journal Title

      Int J Med Sci

      Volume: 10(10) Issue: 10 Pages: 1321-1326

    • DOI

      10.7150/ijms.6631

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Immunohistochemical Changes of Heat Shock Protein 27 Expression in the Mouse Periodontal Tissues Exposed to Orthodontic Mechanical Stress2012

    • Author(s)
      Maki Tomoda, Rina Muraoka,他4名
    • Journal Title

      J.Hard Tissue Biol.

      Volume: 21(1) Pages: 43-50

    • NAID

      40019731938

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Immunohistochemical Expression of Osterix Appearing in the Mouse Orthodontic Periodontal Tension Sides2012

    • Author(s)
      Toshihisa Harada Rina Muraoka,他6名
    • Journal Title

      J.Hard Tissue Biol.

      Volume: 21(3) Pages: 321-328

    • NAID

      130004480569

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Immunohistochemical Changes of Heat Shock Protein 27 Expression in the Mouse Periodontal Tissues Exposed to Orthodontic Mechanical Stress2012

    • Author(s)
      Tomoda M, Nakano K, Muraoka R, Matsuda H, Yamada K and Kawakami T
    • Journal Title

      Journal of Hard Tissue Biology

      Volume: 21 Issue: 1 Pages: 43-50

    • DOI

      10.2485/jhtb.21.43

    • NAID

      130004480532

    • ISSN
      1341-7649, 1880-828X
    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Immunohistochemical Expression of Osterix Appearing in the Mouse Orthodontic Periodontal Tension Sides2012

    • Author(s)
      Harada T, Nakano K, Matsuda H, Muraoka R, Tomoda M, Yokoi Y, Yamada K and Okafuji N
    • Journal Title

      Journal of Hard Tissue Biology

      Volume: 21 Issue: 3 Pages: 321-328

    • DOI

      10.2485/jhtb.21.321

    • NAID

      130004480569

    • ISSN
      1341-7649, 1880-828X
    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] 実験的歯科矯正力により歯根膜組織に発現するHSP70の役割に関する一考察2011

    • Author(s)
      村岡理奈,他6名
    • Journal Title

      J Hard Tissue Biol.

      Volume: 20 Pages: 175-282

    • NAID

      130004848367

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] 歯科矯正力によりマウス歯周組織に発現するOsterixの免疫組織化学的観察2011

    • Author(s)
      松田浩和,村岡理奈,他3名
    • Journal Title

      JHard Tissue Biol.

      Volume: 20 Pages: 283-288

    • NAID

      130004848368

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] 移植骨髄由来細胞の歯周組織への移動と細胞分化2011

    • Author(s)
      村岡理奈,他8名
    • Journal Title

      J Hard Tissue Bio.

      Volume: 20 Pages: 301-306

    • NAID

      130004848371

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] A Consideration on the Role of HSP70 Appearing in the Periodontal Tissues due to Experimental Orthodontic Force2011

    • Author(s)
      村岡理奈,中野敬介 ,松田浩和,共田真紀, 岡藤範正 ,山田一尋,川上敏行
    • Journal Title

      Journal of Hard Tissue Biology

      Volume: 20 Issue: 4 Pages: 275-282

    • DOI

      10.2485/jhtb.20.275

    • NAID

      130004848367

    • ISSN
      1341-7649, 1880-828X
    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Immunohistochemical Observation of Osterix Appearing in the Mouse Orthodontic Periodontal Tissues2011

    • Author(s)
      松田浩和,原田寿久,村岡理奈,共田真紀, 岡藤範正
    • Journal Title

      Journal of Hard Tissue Biology

      Volume: 20 Issue: 4 Pages: 283-288

    • DOI

      10.2485/jhtb.20.283

    • NAID

      130004848368

    • ISSN
      1341-7649, 1880-828X
    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Transplanted Bone Marrow-derived Cell Migration into Periodontal Tissues and Cell Differentiation2011

    • Author(s)
      村岡理奈,辻極秀次, 中野 敬介 ,片瀬直樹,玉村 亮, 富田 美穂子 , 岡藤 範正 ,長塚 仁, 川 上敏行
    • Journal Title

      Journal of Hard Tissue Biology

      Volume: 20 Issue: 4 Pages: 301-306

    • DOI

      10.2485/jhtb.20.301

    • NAID

      130004848371

    • ISSN
      1341-7649, 1880-828X
    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] マウス歯根膜細胞に発現するHSP47の分子シャペロンとしての可能性2013

    • Author(s)
      村岡理奈,他5名
    • Organizer
      第72回日本矯正歯科学会大会
    • Place of Presentation
      長野県松本市
    • Year and Date
      2013-10-09
    • Related Report
      2013 Final Research Report
  • [Presentation] 歯科矯正学的メカニカルストレスが惹起するHSP47のマウス歯根膜細胞における局在変化2013

    • Author(s)
      村岡理奈,他3名
    • Organizer
      第55回歯科基礎医学会学術大会・総会
    • Place of Presentation
      岡山市岡山県
    • Year and Date
      2013-09-22
    • Related Report
      2013 Final Research Report
  • [Presentation] 歯科矯正学的メカニカルストレスによる歯周組織改造時における細胞動態2013

    • Author(s)
      宮城圭子,村岡理奈,他5名
    • Organizer
      第22回硬組織再生生物学会学術大会・総会
    • Place of Presentation
      鶴見市神奈川県
    • Year and Date
      2013-08-22
    • Related Report
      2013 Final Research Report
  • [Presentation] 歯科矯正学的メカニカルストレスによりマウス歯根膜に発現するHSP47の分子シャペロンとしての可能性2013

    • Author(s)
      村岡理奈,他3名
    • Organizer
      第22回硬組織再生生物学会学術大会・総会
    • Place of Presentation
      鶴見市神奈川県
    • Year and Date
      2013-08-22
    • Related Report
      2013 Final Research Report
  • [Presentation] Cytological Remodeling of the Periodontal Ligament Tissues due to Mechanical Stress2013

    • Author(s)
      Toshiyuki Kawakami, Rina Muraoka,他3名
    • Organizer
      The 37th International Congress of Physiological Sciences
    • Place of Presentation
      Birmingham, UK
    • Year and Date
      2013-07-06
    • Related Report
      2013 Final Research Report
  • [Presentation] Effect of HSP70 in the periodontal ligaments remodeling due to orthodontic force2013

    • Author(s)
      Rina Muraoka,他3名
    • Organizer
      89th congress of the European Orthodontic Society
    • Place of Presentation
      Reykjavik, Iceland
    • Year and Date
      2013-06-29
    • Related Report
      2013 Final Research Report
  • [Presentation] Cell Dynamism of the Periodontal Tissues Remodeling elicited by Orthodontic Mechanical Stress2013

    • Author(s)
      Toshiyuki Kawakami, Rina Muraoka,他3名
    • Organizer
      89th congress of the European Orthodontic Society
    • Place of Presentation
      Reykjavik, Iceland
    • Year and Date
      2013-06-29
    • Related Report
      2013 Final Research Report
  • [Presentation] メカニカルストレスが引き起こすマウス歯根膜組織におけるHSP27の発現変化2011

    • Author(s)
      村岡理奈,,他
    • Organizer
      硬組織再生生物学会総会(第20回)
    • Place of Presentation
      日本大学歯学部(東京都)
    • Related Report
      2011 Research-status Report
  • [Presentation] Immunihistochemical expression of HSP27 in the mouse periodontal tissues due to orthodontic mechanical stress2011

    • Author(s)
      Muraoka R, et al.
    • Organizer
      Meeting of Asian Society of Oral and Maxillofacial Pathology (5th) / Annual meeting of the Japanese society of oral pathology (22th)
    • Place of Presentation
      九州大学医学部(福岡市)
    • Related Report
      2011 Research-status Report
  • [Presentation] 矯正学的牽引側歯根膜に発現するHSP27の骨芽細胞分化誘導の分子シャペロンとしての可能性2011

    • Author(s)
      村岡理奈,他
    • Organizer
      歯科基礎医学会総会(第53回)
    • Place of Presentation
      長良川国際会議場(岐阜市)
    • Related Report
      2011 Research-status Report
  • [Presentation] 歯科矯正力が引き起こすマウス歯根膜細胞におけるHSP27の免疫組織化学的発現変化2011

    • Author(s)
      村岡理奈,他
    • Organizer
      日本矯正歯科学会大会(第70回,第4回国際会議)
    • Place of Presentation
      名古屋国際会議場(名古屋市)
    • Related Report
      2011 Research-status Report
  • [Presentation] Orthodontic stress as a possible promoter of transplanted bone marrow-derived cell migration into periodontal tissues2011

    • Author(s)
      Muraoka R, et al.
    • Organizer
      SIDO International Congress, Follow-up in Orthodontics (XXIII)
    • Place of Presentation
      ローマカバリエリ(ローマ)
    • Related Report
      2011 Research-status Report
  • [Presentation] Effect of HSP70 in the periodontal ligaments remodeling due to orthodontic force

    • Author(s)
      Muraoka R, Nakano K, Yamada K and Kawakami T
    • Organizer
      89th Congress of the European Orthodontic Society
    • Place of Presentation
      Reykjavik, Iceland
    • Related Report
      2013 Annual Research Report
  • [Presentation] Cell dynamism of the periodontal tissues remodeling elicited by orthodontic mechanical stress

    • Author(s)
      Kawakami T, Nakano K, Tomida M, Muraoka R and Yamada K
    • Organizer
      89th Congress of the European Orthodontic Society
    • Place of Presentation
      Reykjavik, Iceland
    • Related Report
      2013 Annual Research Report
  • [Presentation] Cytological remodeling of the periodontal ligament tissues due to mechanical stress

    • Author(s)
      Kawakami T, Tomida M, Muraoka R, Nakamura T and Nakano K
    • Organizer
      The 37th International Congress of Physiological Sciences
    • Place of Presentation
      Birmingham, UK
    • Related Report
      2013 Annual Research Report
  • [Presentation] 歯科矯正学的メカニカルストレスによりマウス歯根膜に発現する HSP47 の分子シャペロンとしての可能性

    • Author(s)
      村岡理奈,山田一尋,中野敬介,川上敏行
    • Organizer
      第22回 硬組織再生生物学会学術大会・総会
    • Place of Presentation
      鶴見大学歯学部,神奈川県
    • Related Report
      2013 Annual Research Report
  • [Presentation] 歯科矯正学的メカニカルストレスによる歯周組織改造時における細胞動態

    • Author(s)
      宮城圭子,富田美穂子,中野敬介,村岡理奈,中村貴美,岡藤範正,川上敏行
    • Organizer
      第22回 硬組織再生生物学会学術大会・総会
    • Place of Presentation
      鶴見大学歯学部,神奈川県
    • Related Report
      2013 Annual Research Report
  • [Presentation] 歯科的矯正学的メカニカルストレスが惹起するHSP27のマウス歯根膜細胞における局在変化

    • Author(s)
      村岡理奈,中野敬介,山田一尋,川上敏行
    • Organizer
      第55回 歯科基礎医学会学術大会・総会
    • Place of Presentation
      岡山コンベンションセンター,岡山県
    • Related Report
      2013 Annual Research Report
  • [Presentation] マウス歯根膜細胞に発現するHSP47の分子シャペロンとしての可能性

    • Author(s)
      村岡理奈,中野敬介,松田浩和,川上敏行,岡藤範正,山田一尋
    • Organizer
      第72回 日本矯正歯科学会大会
    • Place of Presentation
      キッセイ文化ホール,長野県
    • Related Report
      2013 Annual Research Report
  • [Presentation] Migration and differentiation of transplanted bone marrow-derived cells into periodontal tissues promoted by mechanical stress

    • Author(s)
      Kawakami T
    • Organizer
      Congress of the European Hematology Association (17th)
    • Place of Presentation
      Amsterdam,Holland
    • Related Report
      2012 Research-status Report
  • [Presentation] Migration of the transplanted bone marrow-derived cells into periodontal ligaments due to orthodontic mechanical stress

    • Author(s)
      Tomida M
    • Organizer
      Physiology 2012
    • Place of Presentation
      Edinburgh,UK
    • Related Report
      2012 Research-status Report
  • [Presentation] Transplanted bone marrow-derived cell migration into periodontal tissues induced by orthodontic mechanical stress

    • Author(s)
      Tomida M
    • Organizer
      International Congress of The Transplantation Society (24th)
    • Place of Presentation
      Berlin,Germany
    • Related Report
      2012 Research-status Report
  • [Presentation] 移植骨髄由来細胞の歯周組織への移動と細胞分化へのプロモーターとしての歯科矯正力

    • Author(s)
      村岡理奈
    • Organizer
      日本矯正歯科学会大会(第71回)
    • Place of Presentation
      盛岡市民文化ホール,盛岡市
    • Related Report
      2012 Research-status Report
  • [Presentation] 歯科矯正力による骨形成分化誘導のダイナミクス

    • Author(s)
      村岡理奈
    • Organizer
      日本歯科医学会総会(第22回)
    • Place of Presentation
      大阪国際会議場,大阪市
    • Related Report
      2012 Research-status Report
  • [Presentation] HSP expression as recovery reaction in the periodontal ligament cells to mechanical stress

    • Author(s)
      Muraoka R
    • Organizer
      Asian Congress on Oral and Maxillofacial Surgery (10th)
    • Place of Presentation
      Bali, Indonesia
    • Related Report
      2012 Research-status Report
  • [Book] 歯科矯正力による骨形成分化誘導のダイナミクス,歯界展望特別号2013

    • Author(s)
      村岡理奈,他7名
    • Total Pages
      221
    • Related Report
      2013 Final Research Report
  • [Book] 歯界展望 特別号. 歯界展望 特別号2013

    • Author(s)
      村岡理奈,中野敬介,渡邉武寛,松田浩和,共田真紀,岡藤範正,山田一尋,川上敏行
    • Total Pages
      368
    • Publisher
      医歯薬出版株式会社
    • Related Report
      2013 Annual Research Report
  • [Book] Immunohistochemical basis for orthodontic treatment. in Biochemistry and Histocytochemistry Research Developments2010

    • Author(s)
      Kawakami T, Muraoka R,他5名(Fuchs S and Auer M ed)
    • Publisher
      Nova Science Publishers, Inc
    • Related Report
      2013 Final Research Report

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Published: 2011-08-05   Modified: 2019-07-29  

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