INDUCTION OF DC-SIGN-MEDIATED CROSS-PRIMING BY PERIODONTAL PATHOGENS
| Project/Area Number |
23792464
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Periodontal dentistry
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| Research Institution | Ohu University (2012)
Tohoku University (2011) |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 慢性歯周炎 / 樹状細胞 / サイトカイン / クロスプライミング / 免疫学 / 歯周炎 / IL-33 / CTL / 細胞・組織 |
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| Research Abstract |
We examined the induction of DC-mediated cross-priming upon Porphyromonas gingivalis (P. g) stimulation in vitro. The stimulation of DCs with P. ginduced the upregulation of Ag cross-presentation and of CD86. The enhancement of DC-mediated cross-priming by P. g was suppressed upon co-stimulation with P. g-derived fimbriae. These results may suggest that P. g could evade the induction of DC-mediated cross-priming.
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Report
(3 results)
Research Products
(19 results)
