The function of anti-cardiolipin antibody by periodontal pathogen for neovascular glaucoma

• Project/Area Number: 23792466
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Periodontal dentistry
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: KATAGIRI Sayaka 東京医科歯科大学, 大学院・医歯学総合研究科, 助教 (60510352)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: 歯周病 / 血管新生緑内障 / 自己抗体 / anti-cardiolipin 抗体 / 交差反応 / 糖尿病 / 緑内障 / anti-cardiolipin抗体 / 抗cardiolopin抗体

Research Abstract

We showed the possibility of cross reaction between the anti-SIRVYK antibody (SIRVYK is peptide sequence of leucotoxin C in A. actinomycetencomitans) and TLRVYK peptide on beta 2 GPI. We find the correlation between serum anti-SIRVYK antibody and serum anti-TLRVYK antibody in diabetic patients. These results might suggest that there is a possibility about relationship between periodontal diseases and neovascular glaucoma.

Research Products

• [Journal Article] Effect of glycemic control on periodontitis in type 2 diabetic patients with periodontal disease (2013)
  • Author(s): Katagiri S, Nitta H, Nagasawa T, Izumi Y, Kanazawa M, Matsuo A, Chiba H, Fukui M, Nakamura N, Oseko F, Kanamura N, Inagaki K, Noguchi T, Naruse K, Matsubara T, Miyazaki S, Miyauchi T, Ando Y, Hanada N, Inoue S
  • Journal Title: Journal of Diabetes Investigation Volume: 4(3) Pages: 320-325
• [Journal Article] Histological and SEM analysis of root cementum following irradiation with Er:YAG and CO2 lasers (2013)
  • Author(s): Almehdi A, Aoki A, Ichinose S, Taniguchi Y, Sasaki KM, Ejiri K, Sawabe M, Chui C, Katagiri S, Izumi Y
  • Journal Title: Lasers in Medical Science Volume: 28(1) Pages: 203-213
• [Journal Article] Periodontal treatment with topical antibiotics improves glycemic control in association with elevated serum adiponectin in patients with type 2 diabetes mellitus (2013)
  • Author(s): Bhartia P, Katagiri S, Nitta H, Nagasawa T, Kobayashi H, Takeuchi Y, Izumiyama H, Uchimura I, Inoue S, Izumi Y
  • Journal Title: Obesity Research and Clinical Practice Volume: 7(2)
• [Journal Article] Effect of glycemic control on periodontitis in type 2 diabetic patients with periodontal disease (2013)
  • Author(s): Katagiri S, Inagaki K, et al
  • Journal Title: Journal of Diabetes Investigation Volume: 4 Pages: 320-325
  • DOI: 10.1111/jdi.12026
  • Peer Reviewed
• [Journal Article] The anti-phospholipid antibody-dependent and independent effects of periodontopathic bacteria on threatened preterm labor and preterm birth (2013)
  • Author(s): Ye CC, Katagiri S, Miyasaka N, Bharti P, Kobayashi H, Takeuchi Y, Momohara Y, Sekiguchi M, Takamine S, Nagasawa T, and Izumi Y
  • Journal Title: Arch Gynecol Obstet Volume: 288 Pages: 65-72
  • DOI: 10.1007/s00404-013-2741-z
  • Peer Reviewed
• [Journal Article] Salivary levels of antibacterial peptide (LL-37/hCAP-18) and cotinine in periodontitis patients (2012)
  • Author(s): Takeuchi Y, Nagasawa T, Katagiri S, Kitagawara S, Kobayashi H, Koyanagi T, Izumi Y
  • Journal Title: Journal of Periodontology Volume: 83(6) Pages: 766-772
• [Journal Article] Improvement of glycemic control after periodontal treatment by resolvinggingival inflammation in type 2 diabetic patients with periodontal disease (2012)
  • Author(s): Katagiri S, Nagasawa T, Kobayashi H, Takamatsu T, Bharti P, Izumiyama H, Uchimura I, Tagami T, Suzuki T, Nanbara H, Taniguchi Y, Hayakumo S, Koyanagi T, Himeno-Ando A, Goto M, Kajio H, Takahashi Y, Izumi Y, Noda M
  • Journal Title: Journal of Diabetes Investigation Volume: 3(4) Pages: 402-409
• [Journal Article] Reduced masticatory function innon-elderly obese Japanese adults (2011)
  • Author(s): Katagiri S, Nitta H, Nagasawa T, Izumi Y, Kanazawa M, Matsuo A, Chiba H, Miyazaki S, Miyauchi T, Nakamura N, Oseko F, Kanamura N, Ando Y, Hanada N, Inoue S
  • Journal Title: Obesity Research and Clinical Practice Volume: 5(4)
• [Journal Article] Reduced masticatory function in non-elderly obese Japanese adults. (2011)
  • Author(s): Katagiri S, Nitta H, Nagasawa T, Izumi Y, Kanazawa M, Matsuo A, Chiba H, Miyazaki S, Miyauchi T, Nakamura N, Oseko F, Kanamura N, Ando Y, Hanada N, Inoue S.
  • Journal Title: Obesity Research and Clinical Practice Volume: 5
  • Peer Reviewed
• [Journal Article] Periodontal treatment with topical antibiotics improves glycemic control in association with elevated serum adiponectin in patients with type 2 diabetes mellitus (2011)
  • Author(s): Pariksha Bharti, Sayaka Katagiri, Hiroshi Nitta, Toshiyuki Nagasawa, Hiroaki Kobayashi, Yasuo Takeuchi, Hajime Izumiyama, Isao Uchimura, Shuji Inoue, Yuichi Izumi
  • Journal Title: Obesity Research and Clinical Practice Volume: 5
  • Peer Reviewed
• [Journal Article] The anti-phospholipid antibody-dependent and independent effects ofperiodontopathic bacteria on threatened preterm labor and preterm birth
  • Author(s): Ye C, Katagiri S, Miyasaka N, Bharti P, Kobayashi H, Takeuchi Y, Momohara Y, Sekiguchi M, Takamine S, Nagasawa T, Izumi Y
  • Journal Title: Archives of Gynecology and Obstetrics Volume: (in press)
• [Presentation] Periopathogenic Bacteria in Oral Plaque (2013)
  • Author(s): Ye C, Bharti P, Kobayashi H, Katagiri S, Takeuchi Y, Nagasawa T, Izumi Y
  • Organizer: Saliva and Placenta from PLBW91st General Session & Exhibition of theIADR
  • Place of Presentation: Seattle, USA
• [Presentation] The role of periodontal bacteria on antiphhospholipid syndrome and preterm low birth weight (2012)
  • Author(s): Ye C, Katagiri S, Bharti P, Kobayashi H, Takeuchi Y, Nagasawa T, Izumi Y
  • Organizer: Japan-China Dental Conference 2012
  • Place of Presentation: Sichuan, China
  • Year and Date: 2012-04-27
• [Presentation] Expression of CD14, CD16 and CD45 on monocytes from aggressive periodontitis patients (2012)
  • Author(s): Bharti P, Katagiri1 S, Ye C, Kobayashi H, Takeuchi Y, Nagasawa T, Izumi Y
  • Organizer: EuroPerio7
  • Place of Presentation: Vienna, Austria
• [Presentation] Salivary levels of antibacterial peptide (LL-37/hCAP-18) and cotinine in periodontitis patients (2012)
  • Author(s): Takeuchi Y, Nagasawa T, Katagiri S, Kitagawara S, Kobayashi H, Koyanagi T, Izumi Y
  • Organizer: EuroPerio7
  • Place of Presentation: Vienna, Austria
• [Presentation] 早産・低体重児出産における歯周病に起因したβ2glycoprotein-Iを認識する抗体の役割 (2012)
  • Author(s): 葉暢暢,片桐さやか,バルティパリクシャ,小林宏明,竹内康雄,長澤敏行,和泉雄一
  • Organizer: 第55回春季日本歯周病学会学術大会
  • Place of Presentation: 札幌
• [Presentation] The role of antibodies against periodontal pathogen on preterm birth (2012)
  • Author(s): Ye C, Katagiri S, Bharti P, Kobayashi H, Takeuchi Y, Nagasawa T, Izumi Y
  • Organizer: The 98th Annual Meeting of the American Academy of Periodontology
  • Place of Presentation: Los Angeles, USA
• [Presentation] 歯周炎に罹患した2型糖尿病患者における歯周病治療および糖尿病治療による多施設介入研究 (2012)
  • Author(s): 片桐さやか,新田浩,長澤敏行,泉山肇,内村功,野口俊英,菊池毅,稲垣幸司,松原達昭,成瀬桂子,金澤真雄,松尾朗,千葉博茂,大迫文重,金村成智,福井道明,中村直登,井上修二,和泉雄一
  • Organizer: 第22回日本歯科医学会総会
  • Place of Presentation: 大阪
• [Presentation] 糖尿病・肥満患者における口腔に関する多施設疫学研究 (2012)
  • Author(s): 新田浩,片桐さやか,長澤敏行,和泉雄一,金澤真雄,松尾朗,千葉博茂,宮崎滋,宮内孝,大迫文重,金村成智,福井道明,中村直登,安藤雄一,花田信弘,井上修二.
  • Organizer: 第22回日本歯科医学会総会
  • Place of Presentation: 大阪
• [Presentation] The role of periodontal bacteria on antiphhospholipid syndrome and preterm low birth weight. (2012)
  • Author(s): Changchang Ye
  • Organizer: Japan-China Dental Conference 2012
  • Place of Presentation: Sichuan, China
• [Presentation] The role of antibodies against periodontal pathogen on preterm birth. (2012)
  • Author(s): Changchang Ye
  • Organizer: The 98th Annual Meeting of the American Academy of Periodontology
  • Place of Presentation: Los Angeles, USA
• [Book] プラクティス (2011)
  • Author(s): 片桐さやか,和泉雄一
• [Book] The Bone (2011)
  • Author(s): 和泉雄一、片桐さやか