The effect of Treg-Th17 conversion induced by periodontopathicbacteria on osteoclastogenesis.
| Project/Area Number |
23792469
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Periodontal dentistry
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| Research Institution | Niigata University |
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Principal Investigator |
OKUI Takafumi 新潟大学, 医歯学総合病院, 医員 (10509540)
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| Research Collaborator |
NONAK Yukari 新潟大学, 医歯学総合研究科, 研究員
HONDA Tomoyuki 新潟大学, 医歯学総合研究科, 医員
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | IL-17+FOXP3+細胞 / Th17 / Treg / 歯周炎 / サブセット転換 / IL-17+FOXP3+T細胞 |
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| Research Abstract |
We investigated whether the Treg-Th17 conversion is associated with the pathogenesis of periodontitis. Immunohistological analysis showed that IL-17A+FOXP3+ cells were observed only in periodontitis lesions but not in clinically healthy sites. Next, we established CD4+ T-cell lines from gingival tissues and peripheral blood of periodontitis patients. The proportion of IL-17+FOXP3+ cells in total FOXP3+ cellswas higher in gingival tissue CD4+ T-cell lines compared with peripheral blood CD4+T-cell lines.
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Report
(3 results)
Research Products
(9 results)
