| Project/Area Number |
23792470
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Periodontal dentistry
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| Research Institution | Niigata University |
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Principal Investigator |
HONDA Tomoyuki 新潟大学, 医歯学総合病院, 医員 (30447635)
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| Research Collaborator |
TAKAHASHI Naoki 新潟大学, 大学院・医歯学総合研究科
MIYAUCHI Sayuri 新潟大学, 大学院・医歯学総合研究科
OKUI Takafumi 新潟大学, 医歯学総合病院, 医員
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 歯肉上皮細胞 / IL-17 / IL-17R / Porphyromonas gingivalis / IL-17A / 炎症性サイトカイン / TNF-α |
|---|
| Research Abstract |
In human gingival epithelial cell lines, Epi4 cells, IL-17 up-regulated inflammatory cytokines and chemokines including CXCL8. IL-17, as well as TNF-α, is involved in the regulation of the innate immune response in gingival epithelial cells. Further studies are needed to examine the roles of interactions among periodontopathic bacteria, IL-17A and IL-17C in the pathogenesis of periodontitis.
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