| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
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| Research Abstract |
The ultimate determinant of periodontal disease progression and clinical outcome is the host's immune response. It has been reported that T cells and B cells which infiltrate in chronic obstructive pulmonary disease (COPD) lesions form lymphoid follicles and relate progression. In the present study, we investigate the relation between progression of periodontal disease and extranodal lymphoid neogenesis.
OX40 and OX40L mRNA, which indicate that there is interaction of T-B cells, were detected in periodontal tissues. And both OX40 and OX40L mRNA expression were increased by porhyromonas gingivalis stimulation. Those results suggested that there is T-B cell interaction and it promote periodontal destruction.
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