The role of Follicular helper T cell in Periodontitis regions

• Project/Area Number: 23792472
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Periodontal dentistry
• Research Institution: Niigata University
• Principal Investigator: ITO HARUE 新潟大学, 医歯学系, 助教 (30397145)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
• Keywords: 歯周炎 / TFH / OX40 / follicular helper T cell

Research Abstract

The ultimate determinant of periodontal disease progression and clinical outcome is the host's immune response. It has been reported that T cells and B cells which infiltrate in chronic obstructive pulmonary disease (COPD) lesions form lymphoid follicles and relate progression. In the present study, we investigate the relation between progression of periodontal disease and extranodal lymphoid neogenesis.
OX40 and OX40L mRNA, which indicate that there is interaction of T-B cells, were detected in periodontal tissues. And both OX40 and OX40L mRNA expression were increased by porhyromonas gingivalis stimulation. Those results suggested that there is T-B cell interaction and it promote periodontal destruction.

Research Products

• [Journal Article] The presence of IL-17+/FOXP3+ double-positive cells in periodontitis (2012)
  • Author(s): Okui T, Aoki Y, Ito H, Honda T, Yamazaki K
  • Journal Title: J Dent Res. Volume: 91(6) Pages: 574-9
  • Peer Reviewed
• [Journal Article] Effects of systemic sitafloxacin on periodontal infection control in elderly patients (2012)
  • Author(s): Nakajima T, Okui T, Miyauchi S, Honda T, Shimada Y, Ito H, Akazawa K, Yamazaki K
  • Journal Title: Gerodontology Volume: 29(2) Pages: 1024-32
  • Peer Reviewed
• [Presentation] 歯周ポケットから臨床分離株に対する抗菌薬の有効性, 耐性の検討 (2013)
  • Author(s): 中島貴子, 奥井隆文, 伊藤晴江, 中島麻由佳, 多部田康一, 山崎和久
  • Organizer: 日本歯科保存学会2013年度秋季学術大会(第139回)
  • Place of Presentation: 秋田市
  • Year and Date: 2013-10-17
• [Presentation] 歯周炎患者における塩酸クロルヘキシジンおよびCPC 配合洗口液の抗菌作用 (2013)
  • Author(s): 杉田典子, 中曽根直弘, 花井悠貴, 高橋昌之, 伊藤晴江, 両角俊哉, 久保田健彦, 奥田一博, 吉江弘正
  • Organizer: 第56回秋季日本歯周病学会学術大会
  • Place of Presentation: 前橋市
  • Year and Date: 2013-09-22
• [Presentation] 歯周病安定期治療中の活動性歯周ポケットに対する経口抗菌療法の細菌学的効果(第2報) (2013)
  • Author(s): 中島貴子, 伊藤晴江, 奥井隆文, 中島麻由佳, 宮下博考, 多部田康一, 山崎和久
  • Organizer: 第56回秋季日本歯周病学会学術大会
  • Place of Presentation: 前橋市
  • Year and Date: 2013-09-22
• [Presentation] 歯周病安定期治療中の活動性歯周ポケットに対する2種類の経口抗菌療法の細菌学的効果 (2012)
  • Author(s): 中島貴子, 奥井隆文, 伊藤晴江, 多部田康一, 山崎和久
  • Organizer: 第55回秋期日本歯周病学会学術大会
  • Place of Presentation: つくば市
  • Year and Date: 2012-09-23
• [Presentation] 歯周炎疾患がPCSK9 および脂質プロファイルに及ぼす影響 (2011)
  • Author(s): 宮沢春菜, 本田朋之, 宮内小百合, 青木由香莉, 宮下博考, 高橋直紀, 前川知樹, 奥井隆文, 土門久哲, 伊藤晴江, 中島貴子, 多部田康一, 山崎和久
  • Organizer: 第54回秋季日本歯周病学会学術大会
  • Place of Presentation: 下関市
  • Year and Date: 2011-09-24
• [Presentation] 歯周炎病変部におけるIL-17^+FOXP3^+T 細胞の関与 (2011)
  • Author(s): 奥井隆文, 青木由香莉, 伊藤晴江, 本田朋之, 山崎和久
  • Organizer: 第54回春季日本歯周病学会学術大会
  • Place of Presentation: 福岡市
  • Year and Date: 2011-05-27