Effect of periodontitis and smoking for genome methylation on IL-6 gene promoter region
| Project/Area Number |
23792473
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Periodontal dentistry
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| Research Institution | Niigata University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | IL-6 / DNA メチル化 / 喫煙 / 歯周炎 / 遺伝子解析 |
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| Research Abstract |
Conventional gene polymorphism analysis cannot elucidate the function and activity of the disease sensitivity gene. Also, it is known that discordant exist between polymorphism and protein production in some genes. The possible cause is that the expression of gene information is influenced by DNA methylation modification. Thus, analysis of genome methylation which regulates the gene activity is necessary for research of the disease sensitivity gene. In the study, DNA extracted from blood, gingival crevicular fluid and periodontal tissues samples in the four type subjects (Healthy individuals, periodontitis patients, smoker with/without periodontitis) were used to investigate the effect of periodontitis and smoking for genome methylation on the IL-6 gene promoter region.
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Report
(3 results)
Research Products
(51 results)
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[Presentation] Bacterial counts and serum antibody levels against periodontal bacteria during SPT phase2012
Author(s)
Morozumi T, Nakagawa T, Kawanami M, Takahashi K, Sato S, Saito A, Ogata Y, Minabe M, Izumi Y, Numabe Y, Ito K, Yoshinari N, Noguchi T, Umeda M, Maeda K, Hara Y, Noguchi K, Takashiba S, Kakuta E, Nomura Y, Hanada N, Yoshie H
Organizer
The98th Annual Meeting American Academy of Periodontology in collaboration with the Japanese Society of Periodontology (Research Forum Poster Session)
Place of Presentation
Los Angeles, U.S.A
Related Report
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[Presentation] Gene and protein expression of TNF-α converting enzyme (TACE/ADAM17) and tissue inhibitor of metalloproteinases (TIMP)-3 in gingival tissues from periodontitis patients with drug-induced gingival overgrowth2012
Author(s)
Tomita T, Kubota T, Nakasone N, Iiyama M, Morozumi T, Horimizu M, Abe D, Nagata K, Nohno H, Yoshie H
Organizer
EUROPERIO7 (Poster presentations)
Place of Presentation
Vienna, Austria
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