| Project/Area Number |
23792481
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Periodontal dentistry
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| Research Institution | Nagasaki University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 歯周ポケット形成 / 歯周炎モデル / 歯周ポケット / 免疫複合体 / C5a / LPS / MMPｓ / Desmoglein / Claudin |
|---|
| Research Abstract |
LPS was applied daily onto the palatal gingival sulcus in rat. In the immunized group, attachment loss was observed on day 10. On day 20, bone resorption was also observed. In the non-immunized group, there was no attachment loss and bone resorption on day 10. In the immunized group, on day 10, C1qB was observed in the junctional epithelium and adjacent connective tissue. The presence of C1qB suggests that the formation of immune complexes is involved in this destruction.
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