| Project/Area Number |
23792488
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Periodontal dentistry
|
|---|
| Research Institution | Showa University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
KAMIJO Ryutaro 昭和大学, 歯学部, 教授 (70233939)
YAMADA Atsushi 昭和大学, 歯学部, 講師 (50407558)
|
|---|
| Project Period (FY) |
2011 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
|---|
| Keywords | 歯周免疫機能学 / 骨芽細胞 / 細胞外マトリックス / TNFα |
|---|
| Research Abstract |
POEM(pre-osteoblast epidermal growth factor-like repeat protein with meprin, A5 protein, and receptor protein-tyrosine phosphatase u domain) gene expression was suppressed by TNF-a via NF-kB. Previously, we reported that TGF-ss also suppressed POEM gene expression via ERK1/2 and JNK. Furthermore, we showed that POEM expression suppressed by TGF-ss via smad2.
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