Research Project
Grant-in-Aid for Young Scientists (B)
The calcification of the blood vessel becomes the risk factor by the resistant increase of the blood vessel. Therefore, I started research on the mechanism of the calcification of the blood vessel through periodontal disease in this study. In the periodontal disease inductivity blood vessel calcification model (IL-6 injected to intraoral), atherosclerotic plaque was increased in the IL-6 administrated group. In addition, the calcified degree of the blood vessel was high in the IL-6 administrated group. Furthermore, I performed of the influence on calcification by the inflammatory cytokine (IL-6) addition in human aorta vascular smooth muscle cell (HUVEC). As a result, expression of ALP and RANKL were increased, but the expression of MGP which was a calcified inhibitor did not increase. Therefore, these results suggested that increasing of periodontal disease inductivity cytokines were involved in the calcification of the blood vessel. In future, this study may contributes to elu idation of mechanism in the calcification of arteriosclerosis due to periodontal disease and it will be elucidated in the relation with periodontal disease and calcification of the blood vessel.
All 2012 2011 Other
All Journal Article (7 results) (of which Peer Reviewed: 7 results) Presentation (14 results) Book (2 results)
J Immunol
Volume: 188 Issue: 4 Pages: 1772-1781
10.4049/jimmunol.1101174
Osteoporosis Jpn
Volume: 20 Pages: 470-473
日レ歯誌
Volume: 23 Pages: 27-32
130004565020
日本骨粗鬆症学会誌
日本レーザー歯学会誌
Journal of Bone and Mineral Research
Volume: 26 Issue: 12 Pages: 2978-2990
10.1002/jbmr.490
J Bone Miner Res
Volume: 26 Pages: 2978-2990
