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Analysis study for wound healing process of oral mucositis

Research Project

Project/Area Number 23792496
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Social dentistry
Research InstitutionTohoku University

Principal Investigator

HOSOKAWA Ryoichi  東北大学, 歯学研究科(研究院), 講師 (40547254)

Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords口内炎 / 創傷治癒 / 抗がん剤 / 分子生物学 / 口腔粘膜炎 / 細胞培養 / 亜鉛製剤 / 上皮細胞
Research Abstract

We researched the effect of medication reducing or prohibiting oral mucositis, which is one of severe side effect of chemotherapy and radiotherapy for cancer. It was saying that Hangeshashintou, TJ14 has effect for oral mucositis clinically. Our research indicated this medication inhibited the exacerbation of oral mucositis during radiotherapy for head and neck cancer. We also investigated the pharmacological action of Hangeshashintou by TR146, oral epithelial cell line, culture system. Cell proliferation was increasing on dose-dependent manner. On the other hand, migration assay indicated that Hangeshashintou prohibited cell migration on dose-dependent manner.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (10 results)

All 2014 2013 2012

All Presentation (10 results)

  • [Presentation]2014

    • Author(s)
      山崎佐千子、伊藤恵美、細川亮一
    • Organizer
      周術期等の高度医療を支える歯科医療を具体的に考えるシンポジウム
    • Place of Presentation
      岡山大学
    • Year and Date
      2014-01-26
    • Related Report
      2013 Final Research Report
  • [Presentation] a Kampo medication, inhibit the development of radiotherapy induced oral mucositis head and neck cancer patients2014

    • Author(s)
      Hosokawa R, Tamahara T, Ito E, Tanda N, Iijima W, Dodo M, Kato K, Koseki K. HANGESHASHINTO
    • Organizer
      Multinational Association of Supportive care in Cancer (MASCC)
    • Place of Presentation
      マイアミアメリカ合衆国
    • Related Report
      2013 Final Research Report
  • [Presentation] ミニシンポジウム「予防歯科医学における周術期の口腔機能管理の展開」2014

    • Author(s)
      細川亮一
    • Organizer
      第63回日本口腔衛生学会・総会
    • Place of Presentation
      熊本
    • Related Report
      2013 Final Research Report
  • [Presentation] 東北大学病院におけるがん支持療法としての口腔機能管理の取り組み2014

    • Author(s)
      加藤翼、細川亮一、玉原亨、吉田英子、丹田奈緒子、菅崎将樹、末永華子、百々美奈、伊藤恵美、小関健由
    • Organizer
      第63回日本口腔衛生学会・総会
    • Place of Presentation
      熊本
    • Related Report
      2013 Final Research Report
  • [Presentation] HANGESHASHINTO, a Kampo medication, inhibit the development of radiotherapy induced oral mucositis head and neck cancer patients2014

    • Author(s)
      Hosokawa R, Tamahara T, Ito E, Tanda N, Iijima W, Dodo M, Kato T, Koseki T
    • Organizer
      MASCC
    • Place of Presentation
      マイアミ アメリカ合衆国
    • Related Report
      2013 Annual Research Report
  • [Presentation] The situation of oral care in Tohoku University hospital after national health insurance coverage to oral management2013

    • Author(s)
      Tamahara T, Hosokawa R, Yoshida E, Tanda N, Ito E, Koseki T
    • Organizer
      Multinational Association of Supportive care in Cancer (MASCC)
    • Place of Presentation
      ベルリンドイツ連邦共和国
    • Related Report
      2013 Final Research Report
  • [Presentation] The situation of oral care in Tohoku University hospital after national health insurance coverage to oral management2013

    • Author(s)
      Tamahara T, Hosokawa R, Yoshida E, Tanda N, Ito E, Koseki T
    • Organizer
      MASCC
    • Place of Presentation
      ベルリン ドイツ共和国
    • Related Report
      2013 Annual Research Report
  • [Presentation] Oral care support team in Tohoku University2012

    • Author(s)
      Hosokawa R, Tamahara T, Ito E, Tanda N, Yoshida, E, Kojima, K, Koseki, T
    • Organizer
      International Association for Disability & Oral Health (iADH)
    • Place of Presentation
      メルボルンオーストラリア連邦
    • Related Report
      2013 Final Research Report
  • [Presentation] 東北大学病院における病棟患者における口腔ケアの臨床的検討2012

    • Author(s)
      玉原亨、細川亮一、伊藤恵美、吉田英子、丹田奈緒子、小関健由
    • Organizer
      第61回日本口腔衛生学会・総会
    • Place of Presentation
      横須賀
    • Related Report
      2013 Final Research Report
  • [Presentation] Oral care support team in Tohoku University2012

    • Author(s)
      RYOICHI HOSOKAWA
    • Organizer
      iADH
    • Place of Presentation
      メルボルン オーストラリア
    • Related Report
      2012 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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