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The association between serum antibody to the periodontal pathogen and chronic kidney disease

Research Project

Project/Area Number 23792504
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Social dentistry
Research InstitutionNiigata University

Principal Investigator

IWASAKI Masanori  新潟大学, 医歯学総合病院, 助教 (80584614)

Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywords慢性腎臓病 / 歯周病 / 疫学 / 炎症
Research Abstract

Kidney disease is recognized as a global health problem; the estimated number of the people with chronic kidney disease (CKD) in Japan alone is 13.3 million, which represents 12.9% of the population. The aim of this study was to investigate the association between serum antibody to the periodontal pathogen and CKD in Japanese individuals. Data were available from 215 participants aged 79 yrs. We observed a significant association between elevated serum antibody titer to P. gingivalis and decreased kidney function, after controlling for other important health characteristics. The findings of the present study suggest that there is a significant association between elevated serum antibody titer to P. gingivalis and decreased kidney function in the community-based cohort of elderly Japanese. Future studies should evaluate the contribution of periodontal therapy in reducing the risk for the development or progression of CKD.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (13 results)

All 2014 2013 2012 2010 Other

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (6 results) Book (2 results) Remarks (1 results)

  • [Journal Article] Relationship between metabolic syndrome and periodontitis in 80-year-old Japanese subjects2014

    • Author(s)
      Minagawa K, Iwasaki M, Ogawa H (他2名)
    • Journal Title

      J Periodontal Res.

      Volume: (In press)

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Relationship between metabolic syndrome and periodontitis in 80-year-old Japanese subjects2014

    • Author(s)
      Minagawa K, Iwasaki M, Ogawa H, Yoshihara A, Miyazaki H
    • Journal Title

      Journal of Periodontal Research

      Volume: in press

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Serum antibody to Porphyromonas gingivalis in chronic kidney disease2012

    • Author(s)
      Iwasaki M, Taylor GW, Manz MC (他4名)
    • Journal Title

      J Dent Res.

      Volume: 91 Issue: 9 Pages: 828-833

    • DOI

      10.1177/0022034512455063

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Periodontal disease and decreased kidney function in Japanese elderly2012

    • Author(s)
      Iwasaki M, Taylor GW, Nesse W (他3名)
    • Journal Title

      Am J Kidney Dis.

      Volume: 59 Issue: 2 Pages: 202-209

    • DOI

      10.1053/j.ajkd.2011.08.027

    • Related Report
      2013 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Presentation] The Relationship Between Metabolic Syndrome and Periodontitis Among Older Japanese2013

    • Author(s)
      Minagawa K, Iwasaki M, Ogawa H, Yoshihara A, Miyazaki H
    • Organizer
      IADR/AADR/CADR General Session & Exhibition-Seattle
    • Place of Presentation
      WAS, U.S
    • Related Report
      2013 Final Research Report
  • [Presentation] 地域在住女性高齢者における腎機能と歯周組織の炎症部位面積に関する横断調査2013

    • Author(s)
      岩﨑正則,葭原明弘,宮﨑秀夫
    • Organizer
      第62回日本口腔衛生学会・総会
    • Place of Presentation
      松本市
    • Related Report
      2013 Annual Research Report
  • [Presentation] 地域在住高齢者におけるメタボリックシンドロームと歯周病の関連2012

    • Author(s)
      坂入久美子, 岩崎正則, 小川祐司, 葭原明弘, 宮崎秀夫
    • Organizer
      第45回新潟歯学会総会
    • Place of Presentation
      新潟市
    • Year and Date
      2012-04-16
    • Related Report
      2013 Final Research Report
  • [Presentation] 特定健診対象者における歯周疾患スクリーニングテストとメタボリックシンドロームとの関連性2012

    • Author(s)
      岩崎正則, 葭原明弘, 宮崎秀夫
    • Organizer
      第61回日本口腔衛生学会・総会
    • Place of Presentation
      横須賀市
    • Related Report
      2013 Final Research Report
  • [Presentation] 地域在住高齢者におけるメタボリックシンドロームと歯周病の関連2012

    • Author(s)
      坂入久美子, 岩崎正則, 小川祐司, 葭原明弘, 宮崎秀夫
    • Organizer
      第61回日本口腔衛生学会・総会
    • Place of Presentation
      横須賀市
    • Related Report
      2013 Final Research Report
  • [Presentation] Periodontal disease may affect kidney function in a community-based Japanese older population2010

    • Author(s)
      Iwasaki M, Yoshihara A, Miyazaki H
    • Organizer
      第59回日本口腔衛生学会・総会
    • Place of Presentation
      新潟市
    • Related Report
      2013 Final Research Report
  • [Book] 腎臓く2014>,歯周病と腎機能2014

    • Author(s)
      岩崎正則, 葭原明弘, 宮崎秀夫, AnnualReview
    • Publisher
      中外医学社
    • Related Report
      2013 Final Research Report
  • [Book] Annual review 腎臓20142014

    • Author(s)
      岩崎正則・葭原明弘・宮崎秀夫
    • Total Pages
      294
    • Publisher
      中外医学社
    • Related Report
      2013 Annual Research Report
  • [Remarks]

    • URL

      http://www.dent.niigata-u.ac.jp/prevent/japanese/publications.html

    • Related Report
      2013 Final Research Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

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