Clinical application of genetic tests regarding cariogenicity of Streptococcus mutans
Project/Area Number |
23792506
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Social dentistry
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Research Institution | Niigata University |
Principal Investigator |
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Project Period (FY) |
2011 – 2013
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Project Status |
Completed (Fiscal Year 2013)
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Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
Keywords | 歯学 / Streptococcus mutans / 齲蝕原性 / ミュータンスレンサ球菌 |
Research Abstract |
An important virulence factor of S. mutans is a glucosyltransferase synthesizing water-insoluble glucan (WIG) from sucrose. We performed sequencing of the gtfB gene of S. mutans isolates derived from primary school students. GtfB coded by gtfB gene possess two functional domain. The carboxyl-terminal portion of GtfB is called the glucan binding domain and is coded by the direct repeating units. The results of this study indicated that the substitution of 33rd amino acid Gly to Ser in the repeating unit is associated with WIG synthesis by S. mutans. And we revealed that the p.G33S substitution is associated with caries development in 1 year in the students using a fluoride mouth rinse.
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Report
(4 results)
Research Products
(14 results)
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[Presentation] 口腔乾燥症診断シート導入の試み2013
Author(s)
伊藤加代子,船山さおり,勝良剛詞,金子昇,濃野要,山田亜紀,井上誠
Organizer
第23回日本口腔内科学会第26回日本口腔診断学会合同学術大会
Place of Presentation
東京,日本口腔診断学会総会プログラム・抄録集,125, 2013
Related Report
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[Presentation] 男性におけるドライシンドローム有訴率に関する検討2013
Author(s)
伊藤加代子,濃野要,船山さおり,金子昇,山田亜紀,畠山文,佐々木綾子,井上誠
Organizer
日本老年歯科医学会第24回学術大会
Place of Presentation
大阪市,老年歯科医学,28(2): 225, 2013
Related Report
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