| Project/Area Number |
23792512
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Social dentistry
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| Research Institution | Okayama University |
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Principal Investigator |
EKUNI Daisuke 岡山大学, 岡山大学病院, 講師 (70346443)
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| Research Collaborator |
MORITA Manabu 岡山大学, 大学院・医歯薬学総合研究科, 教授 (40157904)
TOMOFUJI Takaaki 岡山大学, 岡山大学病院, 講師 (80335629)
AZUMA Tetsuji 岡山大学, 大学院・医歯薬学総合研究科, 助教 (80432649)
ENDO Yasumasa 岡山大学, 岡山大学病院, 医員 (50580213)
IRIE Koichiro 岡山大学, 岡山大学病院, 医員 (50509594)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 歯学 / アルツハイマー病 / 咬合異常 / アミロイドβ |
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| Research Abstract |
The purpose of the present study was to investigate the effects of apolipoprotein E (apoE) deficiency and occlusal disharmony on Amyloid-β (Aβ) production and spatial memory. Wild-type (WT) (n = 12) and apoE-deficient [ApoE(-/-)] (n = 12) rats (Sprague-Dawley; 8 weeks old) were used. In both genotypes of rats, significant differences in the reference memory and Aβ42 production were observed between the control and occlusal disharmony groups. However, no significant differences in these parameters were found between the two genotypes with occlusal disharmony. In conclusion, occlusal disharmony induces cognitive dysfunction and Aβ accumulation in the rat hippocampus, and occlusal disharmony abolishes the differences between genotypes.
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