Investigation of trehalose consumption to prevent periodontitis

• Project/Area Number: 23792513
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Social dentistry
• Research Institution: Okayama University
• Principal Investigator: ENDO Yasumasa 岡山大学, 岡山大学病院, 医員 (50580213)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 動物実験 / 破骨細胞 / 歯周炎 / トレハロース / ラット

Research Abstract

In this study, we investigated the preventive effects of trehalose on osteoclast differentiation in ligature-induced periodontitis in rats. As a result, trehalose could suppress osteoclast differentiation in alveolar bone via inactivation of TLR4 and PKC/ERK pathway in the rat periodontitis model.

Research Products

• [Journal Article] Preventive effects of trehalose on osteoclast differentiation in rat periodontitis model (2013)
  • Author(s): Endo Y, Tomofuji T, Ekuni D, Azuma T, IrieK, Kasuyama K, Morita M
  • Journal Title: Journal of Clinical Periodontology Volume: 40巻 Pages: 33-40
  • NAID: 120005311987
  • Peer Reviewed
• [Journal Article] Preventive effects of trehalose on osteoclast differentiation in rat periodontitis model (2013)
  • Author(s): Yasumasa Endo
  • Journal Title: Journal of Clinical Periodontology Volume: 40 Issue: 1 Pages: 33-40
  • DOI: 10.1111/jcpe.12032
  • NAID: 120005311987
• [Presentation] Trehalose suppress osteoclast differentiation on alveolar bone through inactivation of PKC/ERK pathway in rat periodontitis model (2012)
  • Author(s): Yasumasa Endo
  • Organizer: American Academy of Periodontology 98thAnnual Meeting
  • Place of Presentation: アメリカ、ロサンゼルス
  • Year and Date: 2012-10-02
• [Presentation] Trehalose suppresses osteoclast differentiation in rat periodontitis (2012)
  • Author(s): Yasumasa Endo
  • Organizer: 91th General Session & Exhibition of the IADR
  • Place of Presentation: ブラジル、イグアス
  • Year and Date: 2012-06-23
• [Presentation] TREHALOSE SUPPRESS OSTEOCLAST DIFFERENTIATION ON ALVEOLAR BONE THROUGH INACTIVATION OF PKC/ERK PATHWAY IN RAT PERIODONTITIS MODEL (2012)
  • Author(s): Yasumasa Endo
  • Organizer: American Academy of Periodontology 98th Annual Meeting
  • Place of Presentation: アメリカ、ロサンゼルス