Investigation of trehalose consumption to prevent periodontitis
| Project/Area Number |
23792513
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Social dentistry
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| Research Institution | Okayama University |
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Principal Investigator |
ENDO Yasumasa 岡山大学, 岡山大学病院, 医員 (50580213)
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| Project Period (FY) |
2011 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 動物実験 / 破骨細胞 / 歯周炎 / トレハロース / ラット |
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| Research Abstract |
In this study, we investigated the preventive effects of trehalose on osteoclast differentiation in ligature-induced periodontitis in rats. As a result, trehalose could suppress osteoclast differentiation in alveolar bone via inactivation of TLR4 and PKC/ERK pathway in the rat periodontitis model.
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Report
(3 results)
Research Products
(5 results)
