Role of adipokines and free fatty acids in periodontal disease

• Project/Area Number: 23792523
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Social dentistry
• Research Institution: Nihon University
• Principal Investigator: KAMIO Noriaki 日本大学, 歯学部, 助教 (60546472)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 歯周病 / アディポカイン / 遊離脂肪酸 / メタボリックシンドローム

Research Abstract

Palmitic acid, a saturated fatty acid, enhanced Porphyromonas gingivalis LPS-induced IL-6 production in murine macrophage-like cells. Vaspin, anadipocytes-derived cytokine, inhibited the RANKL-induced osteoclastogenesis in RAW 264.7 cells and bone marrow cells.

Research Products

• [Journal Article] Vaspin Attenuates RANKL-Induced Osteoclast Formation in RAW264.7 Cells. (2013)
  • Author(s): Kamio N, et al.
  • Journal Title: Connect Tissue Res. Volume: 54 Issue: 2 Pages: 147-152
  • DOI: 10.3109/03008207.2012.761978
  • Peer Reviewed
• [Journal Article] Angiotensin II induces the production of MMP-3 and MMP-13 through the MAPK signaling pathways via the AT1 receptor in osteoblasts. (2013)
  • Author(s): Nakai K, et al.
  • Journal Title: Biochimie. Volume: 95 Issue: 4 Pages: 922-933
  • DOI: 10.1016/j.biochi.2012.12.016
  • Peer Reviewed
• [Presentation] Vaspinは破骨細胞への分化を抑制する (2011)
  • Author(s): 神尾宜昌
  • Organizer: 第60回日本口腔衛生学会・総会
  • Place of Presentation: 松戸
  • Year and Date: 2011-10-08
• [Presentation] Vaspin は破骨細胞への分化を抑制する
  • Author(s): 神尾宜昌
  • Organizer: 第６０回日本口腔衛生学会・総会
  • Place of Presentation: 日本大学松戸歯学部（千葉県）
• [Remarks]
  • URL: http://www.dent.nihon-u.ac.jp/bact/index.html