| Project/Area Number |
23792526
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Social dentistry
|
|---|
| Research Institution | The Nippon Dental University |
|---|
Principal Investigator |
OMATA Kazuhiko 日本歯科大学, 生命歯学部, 非常勤講師 (00434142)
|
|---|
| Project Period (FY) |
2011 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
|
|---|
| Keywords | redox / 骨代謝 / 加齢 / 酸化ストレス |
|---|
| Research Abstract |
In this study, we analyzed the molecular mechanism of bone metabolism due to aging changes, using the aging mouse-derived cells. We found that increased expression of redox-related molecules txnip decrease differentiation of osteoclast activity in vitro. The reduction of bone metabolic function due to aging, txnipmay regulate osteoclast genesis.
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