Elucidate molecular biological mechanisms involved in oxidative stress-mediated periodontitis

• Project/Area Number: 23792531
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Social dentistry
• Research Institution: Osaka Dental University
• Principal Investigator: YOSHIKAWA Yoshihiro 大阪歯科大学, 歯学部, 助教 (70434793)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 骨代謝 / 骨芽細胞 / 破骨細胞 / BMP-2 / 国際情報交流

Research Abstract

Periodontitis is a set of inflammatory diseases affecting the periodontium. Bacteria cause progressive bone loss. But it is not clear the mechanism. I elucidated that bone formation factor plays the role of not only bone formation, but also bone resorption.

Research Products

• [Journal Article] Ikeo T Insulin-like growth factor-II promotes proliferation of human periodontal ligament fibroblasts via expression of early growth response transcription factors (2012)
  • Author(s): Tamura I, Kamada A, Goda S, Yoshikawa Y, Domae E
  • Journal Title: Journal of Oral Tissue Engineering Volume: 10 Pages: 13-20
  • Peer Reviewed
• [Journal Article] Fabrication of Hydroxyl Apatite Coating Titanium Web Scaffold Using Pulsed Laser Deposition (2012)
  • Author(s): Hontsu S, Hashimoto Y, Yoshikawa Y, Kusunoki M, Nishikawa H, Ametani A
  • Journal Title: Journal of Hard Tissue Biology Volume: 21 Pages: 181-188
  • Peer Reviewed
• [Journal Article] Insulin-like growth factor-II promotes proliferation of human periodontal ligament fibroblasts via expression of early growth response transcription factors. (2012)
  • Author(s): Tamura I, Kamada A, Goda S, Yoshikawa Y, Domae E, Ikeo T
  • Journal Title: Journal of Oral Tissue Engineering Volume: 10(1) Pages: 13-20
  • NAID: 130004941073
  • Peer Reviewed
• [Journal Article] Economides AN, Kousteni S Genetic evidence points to an osteocalcin-independent influence of osteoblasts on energy metabolism (2011)
  • Author(s): Yoshikawa Y, Kode A, Xu L, Mosialou I, Silva BC, Ferron M, Clemens TL
  • Journal Title: Journal of Bone Minereral Research Volume: 26 Pages: 2012-25
  • Peer Reviewed
• [Journal Article] Genetic evidence points to an osteocalcin-independent influence of osteoblasts on energy metabolism (2011)
  • Author(s): Yoshikawa Y, Kode A, Xu L, Mosialou I, Silva BC, Ferron M, Clemens TL, Economides AN, Kousteni S
  • Journal Title: Journal of Bone and Mineral Research Volume: Volume 26, Issue 9 Issue: 9 Pages: 20122025-20122025
  • DOI: 10.1002/jbmr.417
  • Peer Reviewed
• [Presentation] Statin Regulates Runx2Expression in Human Dental Pulp Stem Cells (2013)
  • Author(s): Kamada A, Ikeo T, Tamura I, Goda S,Yoshikawa Y, Domae E, Yoshimoto H, Kakudo K
  • Organizer: 91st General Session & Exhibition of the IADR
  • Place of Presentation: Seattle, WA, USA
  • Year and Date: 2013-03-23
• [Presentation] マウス骨芽細胞におけるSmad1を介したVDRの発現 (2013)
  • Author(s): 吉川美弘,川本章代,堂前英資,合田征司,田村功,鎌田愛子,小正裕,池尾隆
  • Organizer: 第11回日本歯科骨粗鬆症研究会学術大会・総会
  • Place of Presentation: 東京
  • Year and Date: 2013-03-02
• [Presentation] Ikeo T BMP-2 Promotes Osteoclast Differentiation by Enhancing the Activity of Smad1.American Society for Bone and MineralResearch (2012)
  • Author(s): Yoshikawa Y, Kamada A, Tamura I, Goda S, Domae E
  • Organizer: 2012 Annual Meeting
  • Place of Presentation: Minneapolis, Minnesota, USA
  • Year and Date: 2012-10-15
• [Presentation] 池尾隆骨芽細胞による破骨細胞分化にはSmad1が関与する (2012)
  • Author(s): 吉川美弘,竹山旭,川本章代,田村功,鎌田愛子,小正裕,森田章介
  • Organizer: 第30回日本骨代謝学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2012-07-21
• [Presentation] Fujita T Statin suppresses excess Runx2 expression in human osteoblastic osteosarcoma cells (2011)
  • Author(s): Ikeo T, Kamada A, Yoshikawa Y, Domae E, Goda S, Tamura I, Takaishi Y
  • Organizer: American Society for Bone and Mineral Research 2011Annual Meeting
  • Place of Presentation: San Diego, CA, USA
  • Year and Date: 2011-09-19
• [Presentation] Tamura I Collagen-mimetic peptide of adiponectin accelerates osteoblastic differentiation (2011)
  • Author(s): Kamada A, Ikeo T, Yoshikawa Y, Domae E, Goda S
  • Organizer: American Society for Bone and Mineral Research 2011 Annual Meeting
  • Place of Presentation: San Diego, CA, USA
  • Year and Date: 2011-09-17
• [Presentation] 池尾隆歯根膜細胞においてVDR発現が破骨細胞分化因子を調節する (2011)
  • Author(s): 吉川美弘,川本章代,新原拓也,竹山旭,堂前英資,合田征司,田村功,鎌田愛子,森田章介,岡崎定司,小正裕
  • Organizer: 第9回日本再生歯科医学会
  • Place of Presentation: 大阪市
  • Year and Date: 2011-09-10
• [Presentation] BMP-2 Promotes Osteoclast Differentiation by Enhancing the Activity of Smad1
  • Author(s): Yoshikawa Y, Kamada A, Tamura I, Goda S, Domae E, Ikeo T
  • Organizer: American Society for Bone and Mineral Research 2012 Annual Meeting
  • Place of Presentation: Minneapolis, Minnesota, USA
• [Presentation] 骨芽細胞による破骨細胞分化にはSmad1が関与する
  • Author(s): 吉川 美弘, 堂前 英資, 合田 征司, 田村 功, 鎌田 愛子, 池尾 隆
  • Organizer: 第22回日本歯科医学会総会
  • Place of Presentation: 大阪市
• [Presentation] マウス骨芽細胞におけるSmad1を介したVDRの発現
  • Author(s): 吉川 美弘, 川本 章代, 堂前 英資, 合田 征司, 田村 功, 鎌田 愛子, 小正 裕, 池尾 隆
  • Organizer: 第11回日本歯科骨粗鬆症研究会学術大会・総会
  • Place of Presentation: 東京