Fundamental research on prognostic prediction of pressure ulcers

Research Project

Project/Area Number	23792562
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Fundamental nursing
Research Institution	Teikyo University
Principal Investigator	Arai Naoko 帝京大学, 医療技術学部, 准教授 (10432303)
Project Period (FY)	2011-04-28 – 2017-03-31
Project Status	Completed (Fiscal Year 2016)
Budget Amount *help	¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000) Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000) Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000) Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords	褥瘡 / アセスメント / MMP-9 / BMP-6 / MMP / BMP
Outline of Final Research Achievements	In this study, in order to utilize the biopolymer to evaluate the wound leading to prediction of the pressure ulcer prognosis, we considered proteins considered to be involved in wound healing contained in exudate collected from the wound of pressure ulcer. As a result, it was possible to find a relationship between detection amounts of matrix metalloprotease-9 and bone morphogenetic protein-6 and some of the DESIGN-R scores. From these results, it was shown that MMP-9 and BMP-6 are effective polymeric markers for judging the qualitative state of wounds and can be used as an evaluation tool.