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Cortical laminar units for associative memory in primates: a combinational approach with MRI, electrophysiology and histology.

Research Project

Project/Area Number 23800017
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Neuroscience in general
Research InstitutionThe University of Tokyo

Principal Investigator

KOYANO Kenji  東京大学, 大学院・医学系研究科, 特任助教 (90613315)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
KeywordsMRI / 皮質層構造 / 電気生理 / 連合記憶 / 高次認知機能 / 霊長類 / エルジロイ / 微小電極
Research Abstract

The cerebral cortices were highly developed tissue in primates and important for higher cognitive functions such as associative memory. Although characteristic six-layered structures of the cortices were well known by classical anatomical studies, functional significance of the laminar structure, especially in the processing of higher cognitive functions, remains to be elucidated. In this study, I took a new combinational approach with MRI, electrophysiology and histology, and found functional laminar differences of the primate cerebral cortices in the associative memory processing.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • Research Products

    (10 results)

All 2013 2012 2011

All Journal Article (6 results) (of which Peer Reviewed: 2 results) Presentation (4 results)

  • [Journal Article] fMRI activity in the macaque cerebellum evoked by intracortical microstimulation of the primary somatosensory cortex : evidence for polysynaptic propagation2012

    • Author(s)
      Matsui, T, Koyano, KW, Tamura, K, Osada, T, Adachi, Y, Miyamoto, K, Chikazoe, J, Kamigaki, K, Miyashita, Y
    • Journal Title

      PLoS ONE

      Volume: 7 Issue: 10 Pages: e47515-e47515

    • DOI

      10.1371/journal.pone.0047515

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Direct comparison of spontaneous functional connectivity and effective connectivity measured by intracortical microstimulation : an FMRI study in macaque monkeys2011

    • Author(s)
      Matsui T, Tamura K, Koyano KW, Takeuchi D, Adachi Y, Osada T, Miyashita Y
    • Journal Title

      Cerebral Cortex

      Volume: 21 Issue: 10 Pages: 2348-2356

    • DOI

      10.1093/cercor/bhr019

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Similarities and differences of functional connectivity as measured by spontaneous correlation of fMRI signals and effectiveconnectivity as measured by simultaneous intracortical microstimulation and fMRI2011

    • Author(s)
      Matsui T, Koyano KW, Tamura K, Watanabe T, Takeuchi D, Adachi Y, Osada T, Miyashita Y
    • Journal Title

      Neuroscience Research

      Volume: 71 Suppl 1 Pages: 88-88

    • URL

      http://www.sciencedirect.com/science/journal/01680102/71/supp/S

    • Related Report
      2012 Final Research Report
  • [Journal Article] Selective visualization of rodent and macaque neural circuits using transsynaptic and stationary markers driven by a 2A-based bicistronic lentiviral vector2011

    • Author(s)
      Ohashi Y, Tsubota T, Sato A, Koyano KW, Tamura K, Matsuyama M, Yaguchi M, Wang N, Miyashita Y
    • Journal Title

      Neuroscience Research

      Volume: 761 Suppl 1 Pages: 411-411

    • URL

      http://www.sciencedirect.com/science/journal/01680102/71/supp/S

    • Related Report
      2012 Final Research Report
  • [Journal Article] Similarities and differences of functional connectivity as measured by spontaneous correlation of fMRI signals and effective connectivity as measured by simultaneous intracortical microstimulation and fMRI2011

    • Author(s)
      Matsui T., et al.
    • Journal Title

      Neuroscience Research

      Volume: 71(suppl.)

    • Related Report
      2011 Annual Research Report
  • [Journal Article] Selective visualization of rodent and macaque neural circuits using transsynaptic and stationary markers driven by a 2A-based bicistronic lenti viral vector2011

    • Author(s)
      Ohashi Y., et al.
    • Journal Title

      Neuroscience Research

      Volume: 71(suppl.)

    • Related Report
      2011 Annual Research Report
  • [Presentation] サル下部側頭皮質36野とTE野間を伝達する記憶信号の電気生理学的解析2013

    • Author(s)
      竹田 真己、他
    • Organizer
      第36回日本神経科学大会
    • Place of Presentation
      国立京都国際会館(京都府京都市)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Functionsil Connectivity Analysis of the Inferior Temporal Cortex of Macaque Monkeys2012

    • Author(s)
      松井鉄平, 他
    • Organizer
      グローバルCOEプログラム「生体シグナルを基盤とする統合生命学」第5回国際シンポジウム
    • Place of Presentation
      八ヶ岳ロイヤルホテル(山梨県北杜市)
    • Year and Date
      2012-03-03
    • Related Report
      2011 Annual Research Report
  • [Presentation] 自発活動の相関に基づく機能的結合と微小電気刺激法に基づく機能的結合の相違に関するfMRI研究2011

    • Author(s)
      松井鉄平、小谷野賢治、田村啓太、渡辺朋美、竹内大吾、足立雄哉、長田貴宏、宮下保司
    • Organizer
      第34回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2011-09-17
    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Presentation] 2シストロン性レンチウイルスベクターを用いたラット及びサルの神経回路の選択的可視化法2011

    • Author(s)
      大橋陽平、坪田匡史、佐藤礼奈、小谷野賢治、田村啓太、松山真、矢口雅江、王寧群、宮下保司
    • Organizer
      第34回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2011-09-17
    • Related Report
      2012 Final Research Report 2011 Annual Research Report

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Published: 2011-09-05   Modified: 2019-07-29  

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