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Spatial-temporal structure of synaptic inputs-large-scale spine imaging study-

Research Project

Project/Area Number 23800019
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Neurophysiology and muscle physiology
Research InstitutionThe University of Tokyo

Principal Investigator

TAKAHASHI Naoya  東京大学, 大学院・薬学系研究科, 助教 (80609842)

Research Collaborator KITAMURA Kazuo  東京大学, 大学院・医学系研究科, 准教授 (60423159)
MATSUO Naoki  京都大学, 白眉センター, 准教授 (10508956)
KANO Masanobu  東京大学, 大学院・医学系研究科, 教授 (40185963)
MATSUKI Norio  東京大学, 大学院・薬学系研究科, 教授 (70126168)
IKEGAYA Yuji  東京大学, 大学院・薬学系研究科, 准教授 (10302613)
Project Period (FY) 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords神経科学 / 脳・神経 / 神経 / ニューロン / シナプス / スパイン / 樹状突起 / 回路 / イメージング / カルシウム
Research Abstract

To reveal the spatial geometry of synaptic inputs on dendrites, we optically imaged synaptic activities from hundreds of dendritic spines in hippocampal CA3 pyramidal cells. When a neuron received synchronous synaptic inputs, the coactivated spines tended to be located closely within~10μm along the dendrites. In contrast, synchronous inputs were dispersed over dendrites of fast-spiking basket cells, a subclass of inhibitory interneurons in CA3. Thus, spatial integration of synaptic inputs is cell-type specific.

Report

(2 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • Research Products

    (4 results)

All 2012 2011

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (2 results)

  • [Journal Article] Locally synchronized synaptic inputs2012

    • Author(s)
      Takahashi N, Kitamura K, Matsuo N, Mayford M, Kano M, Matsuki N, Ikegaya Y
    • Journal Title

      Science

      Volume: 335 Pages: 353-6

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Locally Synchronized Synaptic Inputs2012

    • Author(s)
      Naoya Takahashi
    • Journal Title

      Science

      Volume: (in press)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] Locally Synchronized Dendritic Inputs in Hippocampal Pyramidal Cells2012

    • Author(s)
      Takahashi N, Matsuki N, Ikegaya Y
    • Organizer
      8^<th> FENS Forum of Neuroscience
    • Place of Presentation
      バルセロナ
    • Related Report
      2011 Final Research Report
  • [Presentation] Clustered synaptic inputs onto local dendrites : a large-scale spine imaging study2011

    • Author(s)
      Takahashi N, Matsuki N, Ikegaya Y
    • Organizer
      第34回日本神経科学大会
    • Place of Presentation
      横浜
    • Related Report
      2011 Annual Research Report 2011 Final Research Report

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Published: 2011-09-05   Modified: 2016-04-21  

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