Spatial-temporal structure of synaptic inputs-large-scale spine imaging study-
| Project/Area Number |
23800019
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Neurophysiology and muscle physiology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
TAKAHASHI Naoya 東京大学, 大学院・薬学系研究科, 助教 (80609842)
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| Research Collaborator |
KITAMURA Kazuo 東京大学, 大学院・医学系研究科, 准教授 (60423159)
MATSUO Naoki 京都大学, 白眉センター, 准教授 (10508956)
KANO Masanobu 東京大学, 大学院・医学系研究科, 教授 (40185963)
MATSUKI Norio 東京大学, 大学院・薬学系研究科, 教授 (70126168)
IKEGAYA Yuji 東京大学, 大学院・薬学系研究科, 准教授 (10302613)
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| Project Period (FY) |
2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 神経科学 / 脳・神経 / 神経 / ニューロン / シナプス / スパイン / 樹状突起 / 回路 / イメージング / カルシウム |
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| Research Abstract |
To reveal the spatial geometry of synaptic inputs on dendrites, we optically imaged synaptic activities from hundreds of dendritic spines in hippocampal CA3 pyramidal cells. When a neuron received synchronous synaptic inputs, the coactivated spines tended to be located closely within～10μm along the dendrites. In contrast, synchronous inputs were dispersed over dendrites of fast-spiking basket cells, a subclass of inhibitory interneurons in CA3. Thus, spatial integration of synaptic inputs is cell-type specific.
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Report
(2 results)
Research Products
(4 results)
