Research Project
Grant-in-Aid for Research Activity Start-up
We examined whether lactate accumulation associate with exercise-induced mitochondrial biogenesis. We found that dichloroacetate (DCA) injection can decrease muscle and plasma lactate concentration during exercise. DCA injection and exercise were performed in mice for 4 weeks. As a result, the decrease in lactate accumulation by DCA administration attenuated increases in mitochondrial proteins with exercise training. This result suggests that lactate can be a signal for exercise-induced mitochondrial biogenesis in skeletal muscle.
All 2013 2012 2011
All Journal Article (4 results) (of which Peer Reviewed: 2 results) Presentation (8 results) (of which Invited: 1 results)
Appl Physiol Nutr Metab
Volume: 38 Issue: 3 Pages: 326-333
10.1139/apnm-2012-0257
Adaptive medicine
Volume: 4 Pages: 2-9
10.4247/am.2012.abb011
The Journal of Physical Fitness and Sports Medicine
Volume: 1 Issue: 2 Pages: 247-252
10.7600/jpfsm.1.247
10031158951
http://dx.doi.org/
Adaptive Medicine