Functional analysis of STAP2 in the CD8 positive T cells, and application to cancer immunotherapy

• Project/Area Number: 23800031
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Tumor immunology
• Research Institution: Mie University
• Principal Investigator: MURAOKA DAISUKE 三重大学, 大学院医学系研究科, リサーチアソシエイト (20608955)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000); Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 腫瘍免疫 / T細胞 / メモリー細胞 / CD8陽性Ｔ細胞 / CD8陽性T細胞 / STAP2

Outline of Final Research Achievements

STAP2 is an adapter molecule which controls an intracellular signal positively or negatively in various immunological cells. In this study, I investigated the functional mechanism of STAP2 in the differentiation phase of memory CLT. As a result, we revealed that an expression of STAP2 was highly related to the memory phenotype of CTL and STAP2 control the differentiation of memory CTLs.

Research Products

• [Journal Article] Establishment of animal models to analyze the kinetics and distribution of human tumor antigen-specific CD8^+ T cells (2013)
  • Author(s): Muraoka D, Nishikawa H, Noguchi T, Wang L, Harada N, Sato E, Luescher I, Nakayama E, Kato T, Shiku H
  • Journal Title: Vaccine Volume: 31(17) Pages: 2110-2118
  • Peer Reviewed
• [Journal Article] Peptide vaccine induces enhanced tumor growth associated with apoptosis induction in CD8^+ T cells (2010)
  • Author(s): Muraoka D, Kato T, Wang L, Maeda Y, Noguchi T, Harada N, Takeda K, Yagita H, Guillaume P, Luescher I, Old LJ, Shiku H, Nishikawa H
  • Journal Title: J Immunol Volume: 185(6) Pages: 3768-3776
  • Peer Reviewed
• [Presentation] ワクチン抗原のCHPナノゲル複合体化によるリンパ節輸送の促進と抗腫瘍免疫応答の改善 (2012)
  • Author(s): 村岡 大輔、原田 直純、林 妙、吉見 公志、澤田 晋一、秋吉 一成、珠玖 洋
  • Organizer: 第16回日本がん免疫学会総会
  • Place of Presentation: 北海道
  • Year and Date: 2012-07-26
• [Presentation] Control of in vivo spatiotemporal dynamics of antigen and adjuvant by a delivery system CHP nanogel markedly improves the immunogenicity and antitumor efficacy of long peptide cancer vaccine (2012)
  • Author(s): Daisuke Muraoka, Naozumi Harada, Tae Hayashi, Shin-ichi Sawada, Kazunari Akiyoshi, Hiroshi Shiku
  • Organizer: An AACR Special Conference on TUMOR IMMUNOLOGY
  • Place of Presentation: InterContinental Miami Miami Florida
• [Presentation] Antigen delivery system CHP nanogel improves the effect of adjuvants on long peptide cancer vaccines (2011)
  • Author(s): Daisuke Muraoka, Naozumi Harada, Kazunari Akiyoshi, Hiroshi Shiku
  • Organizer: 第70回日本癌学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2011-10-03