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Functional analysis of STAP2 in the CD8 positive T cells, and application to cancer immunotherapy

Research Project

Project/Area Number 23800031
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Tumor immunology
Research InstitutionMie University

Principal Investigator

MURAOKA DAISUKE  三重大学, 大学院医学系研究科, リサーチアソシエイト (20608955)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords腫瘍免疫 / T細胞 / メモリー細胞 / CD8陽性T細胞 / CD8陽性T細胞 / STAP2
Outline of Final Research Achievements

STAP2 is an adapter molecule which controls an intracellular signal positively or negatively in various immunological cells. In this study, I investigated the functional mechanism of STAP2 in the differentiation phase of memory CLT. As a result, we revealed that an expression of STAP2 was highly related to the memory phenotype of CTL and STAP2 control the differentiation of memory CTLs.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • Research Products

    (5 results)

All 2013 2012 2011 2010

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (3 results)

  • [Journal Article] Establishment of animal models to analyze the kinetics and distribution of human tumor antigen-specific CD8^+ T cells2013

    • Author(s)
      Muraoka D, Nishikawa H, Noguchi T, Wang L, Harada N, Sato E, Luescher I, Nakayama E, Kato T, Shiku H
    • Journal Title

      Vaccine

      Volume: 31(17) Pages: 2110-2118

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Peptide vaccine induces enhanced tumor growth associated with apoptosis induction in CD8^+ T cells2010

    • Author(s)
      Muraoka D, Kato T, Wang L, Maeda Y, Noguchi T, Harada N, Takeda K, Yagita H, Guillaume P, Luescher I, Old LJ, Shiku H, Nishikawa H
    • Journal Title

      J Immunol

      Volume: 185(6) Pages: 3768-3776

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Presentation] ワクチン抗原のCHPナノゲル複合体化によるリンパ節輸送の促進と抗腫瘍免疫応答の改善2012

    • Author(s)
      村岡 大輔、原田 直純、林 妙、吉見 公志、澤田 晋一、秋吉 一成、珠玖 洋
    • Organizer
      第16回日本がん免疫学会総会
    • Place of Presentation
      北海道
    • Year and Date
      2012-07-26
    • Related Report
      2012 Final Research Report
  • [Presentation] Control of in vivo spatiotemporal dynamics of antigen and adjuvant by a delivery system CHP nanogel markedly improves the immunogenicity and antitumor efficacy of long peptide cancer vaccine2012

    • Author(s)
      Daisuke Muraoka, Naozumi Harada, Tae Hayashi, Shin-ichi Sawada, Kazunari Akiyoshi, Hiroshi Shiku
    • Organizer
      An AACR Special Conference on TUMOR IMMUNOLOGY
    • Place of Presentation
      InterContinental Miami Miami Florida
    • Related Report
      2012 Final Research Report
  • [Presentation] Antigen delivery system CHP nanogel improves the effect of adjuvants on long peptide cancer vaccines2011

    • Author(s)
      Daisuke Muraoka, Naozumi Harada, Kazunari Akiyoshi, Hiroshi Shiku
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-10-03
    • Related Report
      2012 Final Research Report

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Published: 2011-09-05   Modified: 2019-07-29  

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