Functional analysis of STAP2 in the CD8 positive T cells, and application to cancer immunotherapy
Project/Area Number |
23800031
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Research Category |
Grant-in-Aid for Research Activity Start-up
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Allocation Type | Single-year Grants |
Research Field |
Tumor immunology
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Research Institution | Mie University |
Principal Investigator |
MURAOKA DAISUKE 三重大学, 大学院医学系研究科, リサーチアソシエイト (20608955)
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Project Period (FY) |
2011 – 2012
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Project Status |
Completed (Fiscal Year 2012)
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Budget Amount *help |
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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Keywords | 腫瘍免疫 / T細胞 / メモリー細胞 / CD8陽性T細胞 / CD8陽性T細胞 / STAP2 |
Outline of Final Research Achievements |
STAP2 is an adapter molecule which controls an intracellular signal positively or negatively in various immunological cells. In this study, I investigated the functional mechanism of STAP2 in the differentiation phase of memory CLT. As a result, we revealed that an expression of STAP2 was highly related to the memory phenotype of CTL and STAP2 control the differentiation of memory CTLs.
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Report
(3 results)
Research Products
(5 results)
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[Journal Article] Peptide vaccine induces enhanced tumor growth associated with apoptosis induction in CD8^+ T cells2010
Author(s)
Muraoka D, Kato T, Wang L, Maeda Y, Noguchi T, Harada N, Takeda K, Yagita H, Guillaume P, Luescher I, Old LJ, Shiku H, Nishikawa H
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Journal Title
J Immunol
Volume: 185(6)
Pages: 3768-3776
Related Report
Peer Reviewed
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