A role of neuropilin-1 expressing natural killer cells in breast cancer treatment

• Project/Area Number: 23800036
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Clinical oncology
• Research Institution: Kyoto University
• Principal Investigator: SUZUKI Eiji 京都大学, 医学研究科, 助教 (00612897)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000); Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 乳癌 / トラスツズマブ / ニューロピリン / 単球 / トラスツマブ / ADCC

Research Abstract

We found that nueropilin-1 highly expressing monocyte showed trastuzumab mediated strong antibody dependent cellular cytotoxicity in human breast cancer cell line.

Research Products

• [Presentation] Upregulation of neuropilin-1 in human monocyte is induced by RANKL and may be associated with trastuzumab mediated antibody dependent cellular cytotoxicity (2013)
  • Author(s): 鈴木栄治
  • Organizer: 米国癌学会
  • Place of Presentation: ワシントンDC、米国
• [Presentation] Neurropilin-1 high monocytes play an important role in trastuzumab mediated antibody-dependentcellular cytotoxicity in HER2 positive breast cancer cell lines (2013)
  • Author(s): 河口浩介、鈴木栄治
  • Organizer: 米国癌学会
  • Place of Presentation: ワシントンDC、米国
• [Presentation] Upregulation of neuropilin-1 in human monocyte is induced by RANKL and may be associated with trastuzumab mediated antibody dependent cellular cytotoxicity (2013)
  • Author(s): 鈴木栄治
  • Organizer: 米国癌学会
  • Place of Presentation: ワシントンＤＣ
• [Presentation] Neurropilin-1 high monocytes play an important role in trastuzumab mediated antibody-dependent cellular cytotoxicity in HER2 positive breast cancer cell lines (2013)
  • Author(s): 河口浩介
  • Organizer: 米国癌学会
  • Place of Presentation: ワシントンＤＣ