Analysis of calcium-signaling cascade in the regulation of spermfunction using gene-modified animals
| Project/Area Number |
23800038
|
|---|
| Research Category |
Grant-in-Aid for Research Activity Start-up
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Laboratory animal science
|
|---|
| Research Institution | Osaka University |
|---|
Principal Investigator |
MIYATA Haruhiko 大阪大学, 免疫学フロンティア研究センター, 特任助教 (50604732)
|
|---|
| Project Period (FY) |
2011 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
|---|
| Keywords | 受精 / 精子 / カルシウム |
|---|
| Research Abstract |
I made a knockout(KO) mouse that lacks testis-specific calcineurin to understand its role in the regulation of sperm fertilizing ability. As a result, I found that calcineurin is important to maintain sperm motility and is necessary for fertilization. There were no problems found in the morphology of KO sperm. I also made a knockout mouse that lacks testis-specific calpain that is a calcium-dependent enzyme like calcineurin.
|
Report
(3 results)
Research Products
(7 results)
