Identification of microRNA expression profile of cancer stem cells
Project/Area Number |
23800039
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Research Category |
Grant-in-Aid for Research Activity Start-up
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Allocation Type | Single-year Grants |
Research Field |
Tumor biology
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Research Institution | Osaka University |
Principal Investigator |
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Project Period (FY) |
2011 – 2012
|
Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
Keywords | 癌幹細胞 / マイクロRNA / エクソゾーム / 情報ネットワーク / 骨髄 |
Research Abstract |
In this study, we have identified specific microRNAs that regulate angiogenesis and histone modification in liver cancer stem cell (CSC) fraction. In colorectal cancer, we have also identified microRNA profiles of CSC fraction. These microRNAs were mainly involved in the secretary type and suggested to effect on surrounding microenvironmentfor cancer progression and metastasis.
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Report
(3 results)
Research Products
(13 results)
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[Journal Article] Depletion of JARID1B induces cellular senescence in human colorectal cancer2013
Author(s)
Ohta K, Haraguchi N, Kano Y, Kagawa Y, Konno M, Nishikawa S, Hamabe A, Hasegawa S, Ogawa H, Fukusumi T, Uemura M, Nishimura J, Hata T, Takemasa I, Mizushima T, Noguchi Y, Ozaki M, Kudo T, Sakai D, Satoh T, Fukami M, Ishii M, Yamamot
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Journal Title
Int J Oncol
Volume: 42(4)
Pages: 1212-8
Related Report
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[Journal Article] Reprogramming of gastrointestinal cancer cells2012
Author(s)
Dewi D, Ishii H, Haraguchi N, Nishikawa S, Kano Y, Fukusumi T, Ohta K, Miyazaki S, Ozaki M, Sakai D, Satoh T, Nagano H, Doki Y, Mori M.
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Journal Title
Cancer Sci
Volume: 103(3)
Issue: 3
Pages: 393-9
DOI
Related Report
Peer Reviewed
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[Journal Article] Increased CD13 Expression Reduces Reactive Oxygen Species, Promoting Survival of Liver Cancer Stem Cells via an Epithelial-Mesenchymal Transition-like Phenomenon2011
Author(s)
Kim HM, Haraguchi N, Ishii H, Ohkuma M, Okano M, Mimori K, Eguchi H, Yamamoto H, Nagano H, Sekimoto M, Doki Y, Mori M.
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Journal Title
Ann Surg Oncol
Volume: 31
Issue: S3
Pages: 539-548
DOI
Related Report
Peer Reviewed
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[Journal Article] Reprogramming of Mouse and Human Cells to Pluripotency Using Mature MicroRNAs2011
Author(s)
Miyoshi N, Ishii H, Nagano H, Haraguchi N, Dewi DL,Kano Y, Nishikawa S, Tanemura M, Mimori K, Tanaka F, Saito T, Nishimura J, Takemasa I, Mizushima T, Ikeda M, Yamamoto H, Sekimoto M, Doki Y, Mori M
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Journal Title
Cell Stem Cell
Volume: 8
Issue: 6
Pages: 633-8
DOI
Related Report
Peer Reviewed
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[Journal Article] CD49f-positive cell population efficiently enriches colon cancer cancer-initiating cells
Author(s)
Haraguchi N, Ishii H, Mimori K, OhtaK, Uemura M, Nishimura J, Hata T, Takemasa I, Mizushima T, Yamamoto H, Doki Y, Mori M
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Journal Title
Int J Oncol
Volume: (Accepted)
Related Report
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