Understanding the molecular mechanism required for an anchorage-independent growth of CD133-positive ovarian cancer cells

• Project/Area Number: 23800055
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Tumor biology
• Research Institution: Juntendo University
• Principal Investigator: ARAKI Marito 順天堂大学, 医学研究科, 准教授 (80613843)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000); Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: CD133 / 卵巣癌 / 足場非依存性 / がん幹細胞 / 足場非依存的増殖 / がん性幹細胞

Research Abstract

Solid tumors are comprised of heterogeneous cells, which seem to play crucial roles in the establishment of drug-resistance and the recurrence of tumor. In this study, we identified genes highly expressed in CD133-positive ovarian cancer cells, named themHEG(Highly-expressed genes in CD133-positive cells), and showed that HEG1-3 play an important role for the anchorage-independent cell growth. Further studies would reveal more precise molecular mechanisms of the anchorage-independent cell growth in CD133-positive ovarian cancer cells.

Research Products

• [Journal Article] Inhibition of the NAD-dependent protein deacetylase SIRT2 induces granulocytic differentiation in human leukemia cells (2013)
  • Author(s): Yoshitaka Sunami, Marito Araki, Yumi Hironaka, Soji Morishita, Masaki Kobayashi 、 Ei Leen Liew 、 Yoko Edahiro, Miyuki Tsutsui 、 Akimichi Ohsaka, Norio Komatsu
  • Journal Title: PLoS One Volume: 8(2)
  • Peer Reviewed
• [Journal Article] Inhibition of the Nad-Dependent Protein Deacetylase Sirt2 Induces Granulocytic Differentiation in Human Leukemia Cells (2013)
  • Author(s): Sunami Y, Araki M, Hironaka Y, Morishita S, Kobayashi M, E. L. Liew, Edahiro Y, Tsutsui M, Ohsaka A, Komatsu N
  • Journal Title: PLoS One Volume: 8 Issue: 2 Pages: e57633-e57633
  • DOI: 10.1371/journal.pone.0057633
  • Peer Reviewed
• [Presentation] Inhibition of the NAD-dependent protein deacetylase SIRT2 induces granulocytic differentiation in human leukemia cells (2012)
  • Author(s): Yoshitaka Sunami
  • Organizer: 文部省新学術領域国際シンポジウム「細胞運命制御」
  • Place of Presentation: 京都
• [Presentation] The Sirtuin inhibitor induces APL cell differentiation (2012)
  • Author(s): Yoshitaka Sunami
  • Organizer: The 3rd JSH International Symposium in Kawagoe
  • Place of Presentation: 川越
• [Presentation] The SirT1 Inhibitor Tenovin-6 Induces Monocytic Differentiation in APL Cells (2011)
  • Author(s): 角南義孝、荒木真理人, 他
  • Organizer: 53回米国血液学会(53rd.ASH annual meeting)
  • Place of Presentation: サンディエゴ
  • Year and Date: 2011-12-10
• [Patent(Industrial Property Rights)] 急性前骨髄性白血病治療薬のスクリーニング方法 (2012)
  • Inventor(s): 荒木真理人、小 松則夫、角南義 孝
  • Industrial Property Rights Holder: 荒木真理人、小 松則夫、角南義 孝
  • Filing Date: 2012-08-20
• [Patent(Industrial Property Rights)] 急性前骨髄性白血病治療薬のスクリーニング方法 (2012)
  • Inventor(s): 荒木真理人、小松則夫、角南義孝
  • Industrial Property Rights Holder: 荒木真理人、小松則夫、角南義孝
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2012-181369
  • Filing Date: 2012-08-20