Revelation of linkage between the change of cortical neural activity and the induction mechanism of plasticity during motor learning with the newest optical methods

• Project/Area Number: 23800071
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Neuroscience in general
• Research Institution: National Institute for Basic Biology
• Principal Investigator: MASAMIZU Yoshito 基礎生物学研究所, 光脳回路研究部門, 特別協力研究員 (90608530)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000); Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: カルシウムイメージング / 光子励起顕微鏡 / 運動学習 / 2光子励起顕微鏡 / 2光子カルシウムイメージング / 光遺伝学

Research Abstract

I performed two-photon calcium imaging in L2/3 and L5 of the mouse primary motor cortex during a few weeks of a self-initiated lever-pull task, identifying L2/3 and L5 based on the cortical depth of the imaging plane. During motor learning, increasing firing rate of neurons was frequently observed in L5 than L2/3

Research Products

• [Journal Article] In vivo optogenetic tracing of functional corticocortical connections between motor forelimb areas (2013)
  • Author(s): Riichiro Hira, Fuki Ohkubo, Yasuhiro R. Tanaka, Yoshito Masamizu, George J. Augustine, Haruo Kasai, and Masanori Matsuzaki
  • Journal Title: Frontiers in Neural Circuits Volume: 7巻 Pages: 1-10
  • Peer Reviewed
• [Journal Article] In vivo optogenetic tracing of functional corticocorticai connections between motor forelimb areas (2013)
  • Author(s): Hira R, Ohkubo F, Tanaka YR, Masamizu Y, Augustine GJ, Kasai H, Matsuzaki M
  • Journal Title: Frontiers in Neural Circuits Volume: 7 Pages: 55-55
  • DOI: 10.3389/fncir.2013.00055
  • Peer Reviewed
• [Remarks]
  • URL: http://www.nibb.ac.jp/circuits/