Study of the neural mechanisms involved in the disability of future prediction in depression

• Project/Area Number: 23830088
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Clinical psychology
• Research Institution: Waseda University
• Principal Investigator: KUNISATO Yoshihiko 早稲田大学, 人間科学学術院, 助手 (30613856)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000); Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: うつ病 / 集団認知行動療法 / 遅延割引 / fMRI / 将来予測

Research Abstract

The purpose of this study was to reveal the neural mechanisms involved in the disability of future prediction in depression and the effects of cognitive behavioral therapy. Using the functional magnetic resonance imaging and delay discounting task, we compared depressed patients with healthy controls in the brain activity during delay discounting task. And, patients' brain activity during delay discounting task was compared before cognitive behavioral therapy and after that. As a result, we confirmed that depressed patients show the high delely discounting of loss comparting to healthy controls. We revealed that depressed patients' high delay discounting and neural activity related delay discounting was weakened by the cognitive behavioral therapy.

Research Products

• [Journal Article] Effects of depression on reward-based decision making and variability of action in probabilistic learning. (2012)
  • Author(s): Kunisato Y, Okamoto Y, Ueda K, Onoda K, Okada G, Yoshimura S, Suzuki S, Samejima K, Yamawaki S.
  • Journal Title: Journal of Behavior Therapy and Experimental Psychiatry Volume: 43 Issue: 4 Pages: 1088-1094
  • DOI: 10.1016/j.jbtep.2012.05.007
  • Peer Reviewed
• [Journal Article] Neural and Personality Correlates of Individual Differences Related to the Effects of Acute Tryptophan Depletion on Future Reward Evaluation. (2012)
  • Author(s): Demoto Y, Okada G, Okamoto Y, Kunisato Y, Aoyama S, Onoda K, Munakata A, Nomura M, Tanaka SC, Schweighofer N, Doya K, Yamawaki S.
  • Journal Title: Neuropsychobiology Volume: 65 (2) Issue: 2 Pages: 55-64
  • DOI: 10.1159/000328990
  • Peer Reviewed
• [Journal Article] The effect of negative and positive emotionality on associative memory : an FMRI study (2012)
  • Author(s): Okada G, Okamoto Y, Kunisato Y, Aoyama S, Nishiyama Y, Yoshimura S, Onoda K, Toki S, Yamashita H, Yamawaki S
  • Journal Title: PloS One Volume: 6 Issue: 9 Pages: 1-8
  • DOI: 10.1371/journal.pone.0024862
  • Peer Reviewed
• [Journal Article] 日本語版Environmental Reward Observation Scale (EROS)の作成と信頼性・妥当性の検討 (2011)
  • Author(s): 国里愛彦・高垣耕企・岡島義・中島俊・石川信一・金井嘉宏・岡本泰昌・坂野雄二・山脇成人
  • Journal Title: 行動療法研究 Volume: 37(1) Pages: 21-31
• [Journal Article] Personality traits and the amplitude of spontaneous low-frequency oscillations during resting state (2011)
  • Author(s): Kunisato, Y., et al
  • Journal Title: Neuroscience Letters Volume: 492 Issue: 2 Pages: 109-113
  • DOI: 10.1016/j.neulet.2011.01.067
  • Peer Reviewed
• [Journal Article] Modulation of default-mode network activity by acute tryptophan depletion is associated with mood change : A resting state functional magnetic resonance imaging study (2011)
  • Author(s): Kunisato, Y., et al
  • Journal Title: Neuroscience Research Volume: 69 Pages: 129-134
  • NAID: 10028190643
  • Peer Reviewed
• [Journal Article] Inter-individual discount factor differences in reward prediction are topographically associated with caudate activation (2011)
  • Author(s): Onoda, K., et al
  • Journal Title: Experimental Brain Research Volume: 212 Issue: 4 Pages: 593-601
  • DOI: 10.1007/s00221-011-2771-3
  • Peer Reviewed
• [Journal Article] Cognitive-Behavioral Avoidance Scale (CBAS)日本語版の作成 (2011)
  • Author(s): 高垣耕企, 他
  • Journal Title: 精神科診断学 Volume: 4 Pages: 104-113
  • Peer Reviewed
• [Journal Article] 日本語版Environmental Reward Observation Scale (EROS)の作成と信頼性・妥当性の検討 (2011)
  • Author(s): 国里愛彦, 他
  • Journal Title: 行動療法研究 Volume: 37 Pages: 21-31
  • Peer Reviewed
• [Presentation] 安静時fMRIを用いたBig Five研究の動向とグラフ理論の利用-Network-based statisticを用いた検討- (2012)
  • Author(s): 国里愛彦
  • Organizer: 日本パーソナリティ心理学会第21回大会
  • Place of Presentation: 松江
  • Year and Date: 2012-10-07
• [Presentation] ポジティブおよびネガティブな自動思考のバランスと脳機能の関連-多チャンネルNIRSを用いた検討- (2012)
  • Author(s): 横山仁史・野田隆政・小関俊祐・国里愛彦・伊藤大輔・巣山晴菜・杉村有司・石原奈保子・清水悠・中澤佳奈子・鈴木伸一
  • Organizer: 日本行動療法学会第38回大会
  • Place of Presentation: 京都
  • Year and Date: 2012-09-23
• [Presentation] The Association between Brain's Default Mode Network and Anhedonia: a Resting State FMRI Study (2012)
  • Author(s): Kunisato, Y., Okamoto, Y., Okada, G., Nishiyama, Y., Kanai, Y., Sasaki- Aoki, S., Yoshimura, S., Katsuragawa, T., Suzuki, S., & Yamawaki, S.
  • Organizer: The 12th International Congress of Behavioral Medicine (ICBM)
  • Place of Presentation: Budapest, Hungary.
  • Year and Date: 2012-08-29
• [Presentation] DELAY DISCOUNTING CORRELATED WITH ACC AND PFC : A VBM STUDY (2012)
  • Author(s): Kunisato,Y., Okamoto, Y., Okada, G., Nishiyama, Y., Kanai, Y., Sasaki-Aoki, S., Iwanaga, M., Yamawaki, S.
  • Organizer: The 16th Congress of International Society for Biomedical Research on Alcoholism (ISBRA)
  • Place of Presentation: Sapporo, Japan.
• [Presentation] IMPAIRMENTS OF ATTENTIONAL FUNCTION RELATES TO DEPRESSIVE SYMPTOM DURING ABSTINENCE IN PATIENTS WITH ALCOHOL DEPENDENCE (2012)
  • Author(s): Takebayashi, Y., Tanaka, K., Tukue, R., Okamoto, Y., Kunisato, Y., Okada, G., Tsukue, I., Shimohara, C., Konuma, K., Sugiura, Y., Yamawaki, S.
  • Organizer: The 16th Congress of International Society for Biomedical Research on Alcoholism (ISBRA)
  • Place of Presentation: Sapporo, Japan.
• [Presentation] RELATIONSHIP BETWEEN ATTENTION CONTROL AND EMOTION DYSREGULATION IN ALCOHOL DEPENDENT PATIENTS (2012)
  • Author(s): Tanaka, K., Takebayashi, Y., Tukue, R., Okamoto, Y., Kunisato, Y., Okada, G., Tsukue, I., Shimohara, C., Konuma, K., Sugiura, Y., Yamawaki, S.
  • Organizer: The 16th Congress of International Society for Biomedical Research on Alcoholism (ISBRA)
  • Place of Presentation: Sapporo, Japan.
• [Presentation] RELATIONSHIP BETWEEN DELAY DISCOUNTING, ATTENTION CONTROL AND EMOTIONAL REGULATION IN ALCOHOLISM (2012)
  • Author(s): Tsukue, R., Okamoto, Y., Kunisato, Y., Takebayashi, Y., Tanaka, K., Tsukue, I., Shimohara, C., Konuma, K., Okada, G., Sugiura, Y., Yamawaki, S.
  • Organizer: The 16th Congress of International Society for Biomedical Research on Alcoholism (ISBRA)
  • Place of Presentation: Sapporo, Japan.
• [Presentation] DELAY DISCOUNTING CORRELATED WITH ACC AND PFC: A VBM STUDY (2012)
  • Author(s): Kunisato, Y.
  • Organizer: The 16th Congress of International Society for Biomedical Research on Alcoholism
  • Place of Presentation: Sapporo, Japan
• [Presentation] Hippocampal Activation predicts Treatment Response to Antidepressant for Depression (2011)
  • Author(s): Toki, S., Okamoto, Y., Onoda, K., Yoshimura, S., Kunisato, Y., Okada, G., Yamawaki, S.
  • Organizer: The 50 th annual meeting of American College of Neuropsychopharmacology (ACNP)
  • Place of Presentation: Hawaii, USA.
  • Year and Date: 2011-12-07
• [Presentation] Hippocampal Activation predicts Treatment Response to Antidepressant for Depression (2011)
  • Author(s): Toki, S., et al
  • Organizer: The 50th annual meeting of American College of Neuropsychopharmacology
  • Place of Presentation: ハワイ(アメリカ)
  • Year and Date: 2011-12-07
• [Presentation] 自動思考と客観的および主観的鬱症状との関連 : 多チャンネルNIRSを用いた検討 (2011)
  • Author(s): 横山仁史・野田隆政・小関俊祐・国里愛彦・伊藤大輔・巣山晴菜・杉村有司・石原奈保子・清水悠・中澤佳奈子・鈴木伸一
  • Organizer: 日本行動療法学会第37回大会
  • Place of Presentation: 東京
  • Year and Date: 2011-11-28
• [Presentation] 自動思考と客観的および主観的鬱症状との関連:多チャンネルNIRSを用いた検討 (2011)
  • Author(s): 横山仁史, 他
  • Organizer: 日本行動療法学会第37回大会
  • Place of Presentation: 飯田橋レインボービル(東京都)
  • Year and Date: 2011-11-28
• [Presentation] 長期的な結果を予測した行動選択が回避行動に与える影響の検討 (2011)
  • Author(s): 高垣耕企, 他
  • Organizer: 日本行動療法学会第37回大会
  • Place of Presentation: 飯田橋レインボービル(東京都)
  • Year and Date: 2011-11-27
• [Presentation] 職場サポート要因におけるメンタルヘルスへの影響性の検討 (2011)
  • Author(s): 岡山紀子, 他
  • Organizer: 日本行動療法学会第37回大会
  • Place of Presentation: 飯田橋レインボービル(東京都)
  • Year and Date: 2011-11-27
• [Presentation] 職場における個人要因がうつ症状に及ぼす影響 (2011)
  • Author(s): 宣聖美, 他
  • Organizer: 日本行動療法学会第37回大会
  • Place of Presentation: 飯田橋レインボービル(東京都)
  • Year and Date: 2011-11-27
• [Presentation] 寛解うつ病の脳機能画像研究 (2011)
  • Author(s): 国里愛彦
  • Organizer: 日本心理学会第75回大会
  • Place of Presentation: 日本大学(東京都)
  • Year and Date: 2011-09-15
• [Presentation] 行動活性化/行動抑制システムと安静時の自発的な脳活動との関連 : 安静時 fMRIを用いたデフォルトモードネットワークの観点から (2011)
  • Author(s): 国里愛彦
  • Organizer: パーソナリティ心理学会第20回大会
  • Place of Presentation: 京都
  • Year and Date: 2011-09-04
• [Presentation] 行動活性化/行動抑制システムと安静時の自発的な脳活動との関連:安静時fMRIを用いたデフォルトモードネットワークの観点から (2011)
  • Author(s): 国里愛彦
  • Organizer: パーソナリティ心理学会第20回大会
  • Place of Presentation: 京都光華女子大学(京都府)
  • Year and Date: 2011-09-04
• [Presentation] The volume of right superior temporal gyrus predicts treatment response in treatment-resistant depression patients after cognitive behavioral group therapy. (2011)
  • Author(s): Kunisato, Y., Okamoto, Y., Yoshimura, S., Ueda, K., Matsunaga, M., Okada, G., Onoda, K., Suzuki, S., & Yamawaki, S.
  • Organizer: the 3rd Asian Cognitive Behavior Therapy Conference
  • Place of Presentation: Seoul, Korea.
  • Year and Date: 2011-07-15
• [Presentation] The volume of right superior temporal gyrus predicts treatment response in treatment-resistant depression patients after cognitive behavioral group therapy (2011)
  • Author(s): Kunisato, Y., et al
  • Organizer: The 3rd Asian Cognitive Behavior Therapy Conference
  • Place of Presentation: ソウル(韓国)
  • Year and Date: 2011-07-15
• [Presentation] The relations among the BIS/BAS scale for workplaces, job stressor, and stress response (2011)
  • Author(s): Okayama, N., et al
  • Organizer: The 3rd Asian Cognitive Behavior Therapy Conference
  • Place of Presentation: ソウル(韓国)
  • Year and Date: 2011-07-15
• [Presentation] The relationship between frontal and temporal activation and automatic thoughts: Multi-channel near-infared spectroscopy (NIRS) study. (2011)
  • Author(s): Yokoyama,S., Noda, T., Koseki, S., Ito, D., Kunisato, Y., Suyama, H., Sugimura, Y., Ishihara, N., Shimizu, Y., Nakazawa, K., & Suzuki, S.
  • Organizer: the 3rd Asian Cognitive Behavior Therapy Conference
  • Place of Presentation: Seoul, Korea.
  • Year and Date: 2011-07-14
• [Presentation] Relationship between avoidant behaviors and activation on depressive symptom (2011)
  • Author(s): Takagaki, K., et al
  • Organizer: The 3rd Asian Cognitive Behavior Therapy Conference
  • Place of Presentation: ソウル(韓国)
  • Year and Date: 2011-07-14
• [Presentation] The relationship between frontal and temporal activation and automatic thoughts : Multi-channel near-infared spectroscopy (NIRS) study (2011)
  • Author(s): Yokoyama, S., et al
  • Organizer: The 3rd Asian Cognitive Behavior Therapy Conference
  • Place of Presentation: ソウル(韓国)
  • Year and Date: 2011-07-14
• [Presentation] The Association between Brain’s Default Mode Network and Anhedonia: a Resting State FMRI Study
  • Author(s): Kunisato, Y.
  • Organizer: The 12th International Congress of Behavioral Medicine
  • Place of Presentation: Budapest, Hungary
• [Presentation] 安静時fMRIを用いたBig Five研究の動向とグラフ理論の利用―Network-based statisticを用いた検討―
  • Author(s): 国里愛彦
  • Organizer: 日本パーソナリティ心理学会第21回大会
  • Place of Presentation: 松江
• [Book] うつ病の集団認知行動療法実践マニュアル : 再発予防や復職支援に向けて,鈴木伸一・岡本泰昌・松永美希(編) (2011)
  • Author(s): 松永美希・吉村晋平・国里愛彦・鈴木伸一
  • Publisher: 日本評論社
• [Book] 『うつ病治療ハンドブック 診療のコツ』大野裕(編)「行動活性化療法」 (2011)
  • Author(s): 国里愛彦・岡本泰昌
  • Publisher: 金剛出版
• [Book] うつ病の集団認知行動療法実践マニュアル:再発予防や復職支援に向けて (2011)
  • Author(s): 松永美希・吉村晋平・国里愛彦・鈴木伸一
  • Total Pages: 109
  • Publisher: 日本評論社
• [Book] うつ病の行動活性化療法:新世代の認知行動療法によるブレイクスルー (2011)
  • Author(s): 岡島義, 国里愛彦, 中島俊, 高垣耕企(熊野宏昭, 鈴木伸一監訳)
  • Total Pages: 288
  • Publisher: 日本評論社
• [Book] うつ病治療ハンドブック第2章行動活性化療法 (2011)
  • Author(s): 国里愛彦, 岡本泰昌
  • Total Pages: 365
  • Publisher: 金剛出版