| Budget Amount *help |
¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Research Abstract |
"Photo-polymerizable molecular glue" having guanidinium ion, diaryltetrazole, and olefin was successfully synthesized. Photoirradiation to the monomeric glue resulted in the formation of polymeric molecular glue, which has high capability to adhere to the surface of biomacromolecules. In addition, based on a similar concept to the above, "photoclickable molecular glue", which can convert its non-covalent adhesion to covalent binding by light, was developed. Furthermore, another "photoresponsive molecular glue", which exerts mechanical force to the adhering surface, was also synthesized.
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