| Budget Amount *help |
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Research Abstract |
Small RNA duplexes form the complex termed RISCs. So far, many studies have indentified the essential factors for this complex assembly pathway. However, the sufficient and minimal factors for RISC assembly have been remained unclear. Here, I established a reconstitution system for fly Ago2-RISC assembly. Results of this research project provide the fundamental and important framework for small RNAs, which are known to regulate diverse biological processes including diseases.
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