| Project/Area Number |
23870005
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Molecular biology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
YAMAGISHI Yuya 東京大学, 分子細胞生物学研究所, 助教 (30613096)
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| Project Period (FY) |
2011
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| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 染色体分配 / 分裂酵母 / 紡錘体チェックポイント / 染色体 / 細胞分裂 / 動原体 |
|---|
| Research Abstract |
Bub1 is a conserved kinase which has roles in faithful chromosome segregation. Bub1 localizes at kinetochores in M-phase and this kinetochore localization is essential for its function. However the mechanisms underlying the kinetochore localization of Bub1 remained largely unknown. In this study, we showed that another conserved kinase Mps1 phosphorylates the kinetochore protein Spc7. This phosphorylation promotes the interaction between Bub1 and Spc7, resulting in the kinetochore localization of Bub1.
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