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Regulation of TOR complex 2 by Rab-family G proteins

Research Project

Project/Area Number 23870019
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Cell biology
Research InstitutionNara Institute of Science and Technology

Principal Investigator

SHIOZAKI Kazuhiro  奈良先端科学技術大学院大学, バイオサイエンス研究科, 教授 (00610015)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
KeywordsTOR / TORC2 / Rab タンパク質 / 分裂酵母 / Rabタンパク質 / Target of Rapamycin(TOR) / TOR complex 2(TORC2)
Research Abstract

TOR protein kinase forms two different complexes, one of which is TOR complex 2 (TORC2) that phosphorylates and activates the oncogene product Akt. Akt is known to play key roles in cell proliferation of mammalian early development as well as that of cancerous cells. In addition, the TORC2-Akt pathway mediates insulin signaling to induce glucose uptake in muscle and fat cells. Because TORC2 is highly conserved between human and the fission yeast Schizosaccharomyces pombe, this study utilized fission yeast as a model system to examine the regulatory mechanisms of TORC2 activity. Our results strongly suggest that small GTPases are involved in activation of TORC2. In addition, candidates of novel TORC2 activators have been identified through genetic screens.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • Research Products

    (22 results)

All 2013 2012 2011 Other

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (14 results) (of which Invited: 1 results) Book (2 results) Remarks (3 results)

  • [Journal Article] Response regulator-mediated MAPKKK heteromer promotes stress signaling to the Spc1 MAPK in fission yeast2013

    • Author(s)
      Morigasaki, S., Ikner, A., Tatebe, H., and Shiozaki, K.
    • Journal Title

      Mol Biol Cell

      Volume: 24 Issue: 7 Pages: 1083-92

    • DOI

      10.1091/mbc.e12-10-0727

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] A Photo-triggerable Drug Carrier Based on Cleavage of PEG lipids by Photosensitiser-generated Reactive Singlet Oxygen2013

    • Author(s)
      C. Komeda, A. Ikeda, J. Kikuchi, N. Ishida-Kitagawa, H. Tatebe, K. Shiozaki, M. Akiyama
    • Journal Title

      Org. Biomol. Chem

      Volume: Vol.11, No.16 Issue: 16 Pages: 2567-2570

    • DOI

      10.1039/c2ob27199k

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Phosphorelay-dependent and -independent regulation of MAPKKK by the Mcs4 response regulator in fission yeast

    • Author(s)
      森ヶ崎進、 塩崎 一 裕
    • Journal Title

      Communicative & Integrative Biology

      Volume: vol.6

    • URL

      http://www.landesbioscience.com/journals/cib/article/25020/

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Presentation] キナーゼの基質特異性を決定する分子メカニズム2012

    • Author(s)
      塩崎一裕、TOR
    • Organizer
      日本分子生物学会年会
    • Place of Presentation
      福岡国際会議場(福岡県)
    • Year and Date
      2012-12-13
    • Related Report
      2012 Final Research Report
  • [Presentation] 細胞増殖とインスリンシグナル伝達伝達を担う TOR キナーゼ複合体 TORC2 の機能構築2012

    • Author(s)
      塩崎一裕
    • Organizer
      第29回染色体ワークショップ
    • Place of Presentation
      ホテルニュー水戸屋(宮城県)
    • Year and Date
      2012-01-26
    • Related Report
      2012 Final Research Report
  • [Presentation] 細胞増殖とインスリンシグナル伝達を担うTORキナーゼ複合体TORC2の機能構築2012

    • Author(s)
      塩崎一裕
    • Organizer
      第29回染色体ワークショップ
    • Place of Presentation
      ホテルニュー水戸屋(宮城県)(招待講演)
    • Year and Date
      2012-01-26
    • Related Report
      2011 Annual Research Report
  • [Presentation] Fission yeast as a model system to study TOR complex 2 signaling2011

    • Author(s)
      塩崎一裕
    • Organizer
      7th International Workshop on Cell Regulation in Division and Arrest
    • Place of Presentation
      沖縄科学技術大学院大学(沖縄県)
    • Year and Date
      2011-10-25
    • Related Report
      2012 Final Research Report
  • [Presentation] Fission yeast as a model system to study TOR complex 2 signaling2011

    • Author(s)
      塩崎一裕
    • Organizer
      7th International Workshop on Cell Regulation in Division and Arrest
    • Place of Presentation
      沖縄科学技術大学院大学(沖縄県)(招待講演)
    • Year and Date
      2011-10-25
    • Related Report
      2011 Annual Research Report
  • [Presentation] Fission yeast as a model system to study TOR complex 2 signaling2011

    • Author(s)
      塩崎一裕
    • Organizer
      日本生化学会第84回大会
    • Place of Presentation
      国立京都国際会館(京都府)
    • Year and Date
      2011-09-23
    • Related Report
      2012 Final Research Report
  • [Presentation] Sin1, an essential TOR complex 2 (TORC2) subunit conserved from yeast to man2011

    • Author(s)
      塩崎一裕
    • Organizer
      日本生化学会第84回大会
    • Place of Presentation
      国立京都国際会館(京都府)(招待講演)(シンポジウム・オーガナイザー)
    • Year and Date
      2011-09-23
    • Related Report
      2011 Annual Research Report
  • [Presentation] 分裂酵母の環境ストレス耐性に必須な TOR キナーゼ複合体(TORC2)の制御機構2011

    • Author(s)
      塩崎一裕
    • Organizer
      日本遺伝学会第83回大会
    • Place of Presentation
      京都大学農学部(京都府)
    • Year and Date
      2011-09-20
    • Related Report
      2012 Final Research Report
  • [Presentation] 分裂酵母の環境ストレス耐性に必須なTORキナーゼ複合体(TORC2)の制御機構2011

    • Author(s)
      塩崎一裕
    • Organizer
      日本遺伝学会第83回大会
    • Place of Presentation
      京都大学農学部(京都府)(シンポジウム・オーガナイザー)
    • Year and Date
      2011-09-20
    • Related Report
      2011 Annual Research Report
  • [Presentation] Sin1 - an essential TOR complex 2 (TORC2) subunit conserved from yeast to man2011

    • Author(s)
      塩崎一裕
    • Organizer
      Pombe 2011
    • Place of Presentation
      Harvard Medical School(米国 Boston)
    • Year and Date
      2011-06-28
    • Related Report
      2012 Final Research Report
  • [Presentation] Sin1, an essential TOR complex 2 (TORC2) subunit conserved from yeast to man2011

    • Author(s)
      塩崎一裕
    • Organizer
      Pombe 2011
    • Place of Presentation
      Harvard Medical School、(Boston、米国)(招待講演)
    • Year and Date
      2011-06-28
    • Related Report
      2011 Annual Research Report
  • [Presentation] Sin1 - an essential TOR complex 2 (TORC2) subunit conserved from yeast to man2011

    • Author(s)
      塩崎一裕
    • Organizer
      6th UK-Japan Cell Cycle Workshop
    • Place of Presentation
      Low Wood Hotel (英国 Windermere)
    • Year and Date
      2011-04-12
    • Related Report
      2012 Final Research Report
  • [Presentation] Sin1, an essential TOR complex 2 (TORC2) subunit conserved from yeast to man2011

    • Author(s)
      塩崎一裕
    • Organizer
      6th UK-Japan Cell Cycle Workshop
    • Place of Presentation
      Low Wood Hotel (Windermere、英国)
    • Year and Date
      2011-04-12
    • Related Report
      2011 Annual Research Report
  • [Presentation] TORキナーゼの基質特異性を決定する分子メカニズム

    • Author(s)
      塩崎一裕
    • Organizer
      日本分子生物学会年会
    • Place of Presentation
      福岡国際会議場
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Book] PP2C2012

    • Author(s)
      建部恒、塩崎一裕
    • Publisher
      Springer Science 社
    • Related Report
      2012 Final Research Report
  • [Book] "PP2C" in Encyclopedia of Signaling Molecules2012

    • Author(s)
      建部恒、塩崎一裕
    • Publisher
      Springer Science(in Press)
    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://bsw3.naist.jp/shiozaki/

    • Related Report
      2012 Final Research Report
  • [Remarks] 奈良先端科学技術大学院大学バイオサイエンス研究科 細胞シグナル研究室

    • URL

      http://bsw3.naist.jp/shiozaki/

    • Related Report
      2012 Annual Research Report
  • [Remarks]

    • URL

      http://bsw3.naist.jp/courses/courses304.html

    • Related Report
      2011 Annual Research Report

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Published: 2011-09-05   Modified: 2019-07-29  

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