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Investigation of the homeostatic regulation for organelle abundanceby invention of organelle knockdown-technology

Research Project

Project/Area Number 23870020
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Cell biology
Research InstitutionNara Institute of Science and Technology

Principal Investigator

YANAGITANI Kota  奈良先端科学技術大学院大学, バイオサイエンス研究科, 特任助教 (70614775)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords細胞生物学 / バイオテクノロジー / オルガネラ / ホメオスタシス
Research Abstract

Organelle abundance in eukaryotic cells seems to be tightly regulated. These regulations, however, are poorly understood. The objective of this project was investigation of unknown homeostatic regulation of organelle abundance by invention of organelle-knockdown technology which reduces the amount of specific organelle. In this granted term, I could make a prototype of the organelle knockdown technology, although its efficiency was not high. This system will be applicable to investigation of the homeostatic regulation of organelle abundance by improvement of the system.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • Research Products

    (11 results)

All 2012 2011

All Journal Article (4 results) (of which Peer Reviewed: 1 results) Presentation (7 results)

  • [Journal Article] 小胞体膜上で起こるスプライシングに秘められた巧妙な仕組み2012

    • Author(s)
      柳谷耕太, 河野憲二
    • Journal Title

      化学と生物

      Volume: 50 Pages: 633-640

    • NAID

      10031123204

    • Related Report
      2012 Final Research Report
  • [Journal Article] 小胞体膜状で起こるスプライシングの巧妙な仕組み2012

    • Author(s)
      柳谷耕太, 河野憲二
    • Journal Title

      生化学

      Volume: 84 Pages: 290-294

    • Related Report
      2012 Final Research Report
  • [Journal Article] 小胞体膜上で起こるスプライシングの洗練されたメカニズム2011

    • Author(s)
      柳谷耕太, 河野憲二
    • Journal Title

      実験医学

      Volume: 29 Pages: 1772-1776

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Journal Article] Reconstitution and characterization of the unconventional slicing of XBP1u mRNA in vitro2011

    • Author(s)
      Shinya, S., Kadokura, H., Imagawa, Y., Inoue, M., Yanagitani, K., and Kohno, K.
    • Journal Title

      Nuc. Acids Res

      Volume: 39 Issue: 12 Pages: 5245-5254

    • DOI

      10.1093/nar/gkr132

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] 小胞体膜上で起こるスプライシングの巧妙な仕組み,私立大学戦略的研究基盤形成支援事業「タンパク質の生成と管理」2012

    • Author(s)
      柳谷耕太
    • Organizer
      第6回セミナー(招待講演)
    • Place of Presentation
      京都産業大学
    • Year and Date
      2012-03-08
    • Related Report
      2012 Final Research Report
  • [Presentation] 哺乳動物細胞で機能する翻訳停止配列の開発と応用2011

    • Author(s)
      門井浩二, 柳谷耕太, 河野憲二
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2011-12-15
    • Related Report
      2012 Final Research Report
  • [Presentation] Ribosomal Stalling Promotes mRNA Splicing on the Endoplasmic Reticulum2011

    • Author(s)
      Kota Yanagitani, Yukiko Yokota, Yukio Kimata, Hiroshi Kadokura, Kenji Kohno
    • Organizer
      第34回日本分子生物学会年会 (招待講演)
    • Place of Presentation
      横浜
    • Year and Date
      2011-12-15
    • Related Report
      2012 Final Research Report
  • [Presentation] 小胞体膜上で起こる mRNA スプライシングにおける翻訳停止反応の役割2011

    • Author(s)
      柳谷耕太
    • Organizer
      第63回日本細胞生物学会大会
    • Place of Presentation
      札幌
    • Year and Date
      2011-12-15
    • Related Report
      2012 Final Research Report
  • [Presentation] Ribosomal Stalling Promotes mRNA Splicing on the Endoplasmic Reticulum2011

    • Author(s)
      Kota Yanagitani, Yukiko Yokota, Yukio Kimata, Hiroshi Kadokura, Kenji Kohno
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      横浜市(招待講演)
    • Year and Date
      2011-12-15
    • Related Report
      2011 Annual Research Report
  • [Presentation] 哺乳動物細胞で機能する翻訳停止配列の開発と応用2011

    • Author(s)
      門井浩二、柳谷耕太、河野憲二
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      横浜市
    • Year and Date
      2011-12-15
    • Related Report
      2011 Annual Research Report
  • [Presentation] 小胞体膜上で起こるmRNAスプライシングにおける翻訳停止反応の役割2011

    • Author(s)
      柳谷耕太
    • Organizer
      第63回日本細胞生物学会大会
    • Place of Presentation
      札幌市
    • Year and Date
      2011-06-27
    • Related Report
      2011 Annual Research Report

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Published: 2011-09-05   Modified: 2019-07-29  

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