| Budget Amount *help |
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Research Abstract |
To characterize the conformational dynamics of the active end of amyloid fibril, we attempted to design small-sized amyloid fibril models. We successfully prepared tandem repeats of amyloid β (Aβ) molecules as minimal models of the amyloid fibrils by genetic manipulation. It was revealed that the tandem-repeat Aβ was recognized by the specific antibody directed against the end point of Aβ amyloid fibrils and served as nucleus which promoted the amyloid fibrillization. Furthermore, we found that bacterial molecular chaperones and ganglioside-embedding bicelles could suppress formation of Aβ fibrils.
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