| Project/Area Number |
23880003
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Zootechnical science/Grassland science
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| Research Institution | Tohoku University |
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Principal Investigator |
KIKUSATO Motoi 東北大学, 大学院・農学研究科, 助教 (90613042)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 暑熱 / 酸化ストレス / 脱共役タンパク質 / 活性酸素 / ミトコンドリア / プロトンリーク / 膜電位 / 暑熱ストレス / UCP / オリーブオイル / オレウロペイン / 活性酸素種 / 肉用鶏 / 産卵鶏 |
|---|
| Research Abstract |
On exposure of meat-type chickens to heat stress, avian uncoupling protein (avUCP) expression in the skeletal muscle was decreased, which was involved in the overproduction of mitochondrial reactive oxygen species production (ROS) probably via an increase in the mitochondrial membrane potential. This study demonstrates that the heat stress-induced overproduction of mitochondrial ROS did not occur in the muscle mitochondria of laying-type chickens, whose avUCP expression is relatively higher than that of meat-type ones, and in mitochondria of meat-type chickens whose avUCP expression was up-regulated with dietary intake of olive oil and oleuropein. From these results, it is conceivable that avUCP expression may play an important role in suppressing the overproduction of mitochondrial ROS and oxidative damage caused by heat exposure.
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