Elucidation of immunological mechanisms in swine selected for resistance to Mycoplasmal pneumonia

• Project/Area Number: 23880004
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Applied animal science
• Research Institution: Tohoku University
• Principal Investigator: SHIMAZU Tomoyuki 東北大学, 大学院・農学研究科, 助教 (20616437)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000); Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 抗病性 / ブタ / 免疫

Research Abstract

The immunophenotype of a novel swine line genetically selected to reduce the incidence of pulmonary lesions caused by MPS was analyzed in this study. The reactivity of peripheral blood mononuclear cells stimulated with bacteria-associated component was lower in MPS selected animal rather than conventional pigs, and the reactivity of lymphocyte to MPS vaccine sensitization in vivo was also lower in the MPS selected pigs. Meanwhile, the induction of IFN-g was higher in MPS selected pigs after vaccine sensitization. These immunological characteristics are considered to be important for the reduction of MPS lesions

Research Products

• [Journal Article] Immunological characterization of peripheral blood leukocytes using vaccine for mycoplasmal pneumonia of swine (MPS) in swine line selected for resistance to MPS (2013)
  • Author(s): Shimazu T, Borjigin L, Katayama Y, LiM,Satoh T, Watanebe K, Kitazawa H, Roh S, Aso H, Kazuo K, Suda Y, Sakuma A, Nakajo M, K.Suzuki
  • Journal Title: Animal Science Journal Volume: (In press) Issue: 10 Pages: 683-692
  • DOI: 10.1111/asj.12058
  • Peer Reviewed
• [Presentation] 一般ランドレースと大ヨークシャー種のMPSワクチンに対する免疫応答の比較 (2013)
  • Author(s): 島津朋之・陸拾七・片山雄貴・佐藤匠・大津良輔・遠藤雅士・北澤春樹・麻生久・加藤和雄・須田義人・佐久間晶子・中條満・鈴木啓一
  • Organizer: 日本畜産学会第116回大会
  • Place of Presentation: 広島市,安田女子大学キャンパス
  • Year and Date: 2013-03-30
• [Presentation] 一般ランドレースと大ヨークシャー種のMPSワクチンに対する免疫応答の比較 (2013)
  • Author(s): 島津朋之，ら
  • Organizer: 日本畜産学会 第116回大会
  • Place of Presentation: 安田女子大学, 広島市
• [Presentation] MPS 病変選抜種と末梢血免疫能選抜種豚の肺病変及び MPS ワクチン刺激に対する末梢血免疫応答の比較 (2013)
  • Author(s): 陸拾七，島津朋之，ら
  • Organizer: 日本畜産学会 第116回大会
  • Place of Presentation: 安田女子大学, 広島市
• [Presentation] Changes in peripheral blood leukocytes in swine selected line for resistance to MPS (2012)
  • Author(s): T.Shimazu, J.Riku, Y.Katayama, M.Li, T.Sato, H.Kitazawa, H.Aso, K.Katoh, Y.Suda, A.Sakuma, M.Nakajoh, K.Suzuki
  • Organizer: The 63rd Annual Meeting of the EAAP
  • Place of Presentation: Bratislava, Slovakia
  • Year and Date: 2012-08-29
• [Presentation] MPS選抜系統豚のMPSワクチンに対する獲得免疫応答の比較 (2012)
  • Author(s): 片山雄貴, 島津朋之, ら
  • Organizer: 日本畜産学会第115回大会
  • Place of Presentation: 名古屋大学東山キャンパス
  • Year and Date: 2012-03-29
• [Presentation] MPSワクチン刺激に対する抗病性選抜豚の末梢血中免疫細胞割合の比較 (2012)
  • Author(s): 陸拾七, 島津朋之, ら
  • Organizer: 日本畜産学会第115回大会
  • Place of Presentation: 名古屋大学東山キャンパス
  • Year and Date: 2012-03-29
• [Presentation] マイコプラズマ抗病性選抜豚のMPSワクチン刺激に対する免疫応答 (2012)
  • Author(s): 島津朋之, 陸拾七, ら
  • Organizer: 第96回日本養豚学会
  • Place of Presentation: 武蔵野スイングホール
  • Year and Date: 2012-03-24
• [Presentation] マイコプラズマ抗病性選抜豚のMPSワクチン刺激に対する免疫応答 (2012)
  • Author(s): 島津朋之・陸拾七・片山雄貴・李美花・佐藤匠・北澤春樹・麻生久・加藤和雄・須田義人・佐久間晶子・中條満・鈴木啓一
  • Organizer: 第96回日本養豚学会
  • Place of Presentation: 武蔵野市,武蔵野スイングホール
  • Year and Date: 2012-03-23
• [Presentation] Changes in peripheral blood leukocytes in swine selected line for resistance to MPS (2012)
  • Author(s): T. Shimazu, et al.
  • Organizer: The 63rd Annual Meeting of the EAAP
  • Place of Presentation: Slovak Technical University, Bratislava, Slovakia
• [Presentation] 免疫能選抜豚の免疫応答・抗病性の検討 (2012)
  • Author(s): 陸拾七，島津朋之，ら
  • Organizer: 日本動物遺伝育種学会第13回大会
  • Place of Presentation: 東北大学，仙台市