Investigation into the molecular mechanism of the resolution of glucocorticoid resistance in lymphoma.
| Project/Area Number |
23880009
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Clinical veterinary science
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| Research Institution | Tokyo University of Agriculture and Technology |
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Principal Investigator |
MATSUDA Akira 東京農工大学, 農学府, 助教 (90613969)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | リンパ腫 / グルココルチコイド耐性 / グルココルチコイド受容体 / NF-κB / グルココルチコイド / PU.1 / SRp30c |
|---|
| Research Abstract |
In this research, a novel mechanism of induction of glucocorticoid resistance in lymphoma cells was proposed by analyses of factors that could modulate the expression of glucocorticoid receptors. Furthermore, it was confirmed that inhibition of NF-κB could restore glucocorticoid sensitivity, suggesting that it may be a new strategy for the treatment of lymphoma with glucocorticoid resistance.
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Report
(3 results)
Research Products
(50 results)
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[Journal Article] Daily intake of Jeju groundwater improves the skin condition of the model mouse for human atopic dermatitis.2013
Author(s)
Tanaka A, Jung K, Matsuda A, Jang H, Kajiwara N, Amagai Y, Oida K, Ahn G, Ohmori K, Kang KG, Matsuda H
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Journal Title
Journal of Dermatology
Volume: 40
Issue: 3
Pages: 193-200
DOI
Related Report
Peer Reviewed
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[Journal Article] Supplementation of the fermented soy product ImmuBalanceTM effectively reduces itching behavior of atopic NC/Tnd mice2012
Author(s)
Matsuda A, Tanaka A, Pan W, Okamoto N, Oida K, Kingyo N, Amagai Y, Xia Y, Jang H, Nishikawa S, Kajiwara N, Ahn G, Ohmori K, Matsuda H
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Journal Title
J. Dermatol. Sci
Volume: 67(2)
Issue: 2
Pages: 130-139
DOI
Related Report
Peer Reviewed
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[Journal Article] Peroxisome proliferator-activated receptorγ-mediated suppression of dendritic cell function prevents the onset of atopic dermatitis in NC/Tnd mice2011
Author(s)
Jung K, Tanaka A, Fujita H, Matsuda A, Oida K, Karasawa K, Okamoto N, Ohmori K, Jee Y, Shin T, Matsuda H.
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Journal Title
J Allergy Clin Immunol
Volume: 127
Issue: 2
Pages: 420-429
DOI
Related Report
Peer Reviewed
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[Journal Article] Glucocorticoid sensitivity depends on expression levels of glucocorticoid receptors in canine neoplastic mast cells2011
Author(s)
Matsuda A, Tanaka A, Amagai Y, Ohmori K, Nishikawa S, Xia Y, Karasawa K, Okamoto N, Oida K, Jang H, Matsuda H.
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Journal Title
Vet Immunol Immunopathol
Volume: 144
Issue: 3-4
Pages: 321-328
DOI
Related Report
Peer Reviewed
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