| Project/Area Number |
23880009
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Clinical veterinary science
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| Research Institution | Tokyo University of Agriculture and Technology |
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Principal Investigator |
MATSUDA Akira 東京農工大学, 農学府, 助教 (90613969)
|
|---|
| Project Period (FY) |
2011 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
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| Keywords | リンパ腫 / グルココルチコイド耐性 / グルココルチコイド受容体 / NF-κB / グルココルチコイド / PU.1 / SRp30c |
|---|
| Research Abstract |
In this research, a novel mechanism of induction of glucocorticoid resistance in lymphoma cells was proposed by analyses of factors that could modulate the expression of glucocorticoid receptors. Furthermore, it was confirmed that inhibition of NF-κB could restore glucocorticoid sensitivity, suggesting that it may be a new strategy for the treatment of lymphoma with glucocorticoid resistance.
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