Methodology development for acquisition of a numerous number of new natural products from filamentous
| Project/Area Number |
23880025
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Applied microbiology
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| Research Institution | University of Shizuoka |
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Principal Investigator |
NAKAZAWA Takehito 静岡県立大学, 大学院・薬学研究科, 客員共同研究員 (80608141)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 糸状菌 / 酵母 / 生合成 / 異種発現 / 二次代謝 / 形態形成 / 天然物化学 / 遺伝子工学 / ケミカルジェネティクス |
|---|
| Research Abstract |
A number of biosynthetic genes for fungal secondary metabolites were successfully reconstructed in yeast cells, and I successfully obtained natural products biosynthesized by them through heterologous production in yeast. I also developed molecular genetics systems for biosynthetic studies in some filamentous fungi. And I obtained a number of natural products, some of which are new/novel, through disruptions of genes involved in regulation of biosynthetic genes. I then found that several secondary metabolites are involved in regulation of transcription and sexual development (formation of sexual spores) in Chaetomium globosum.
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Report
(3 results)
Research Products
(36 results)
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[Presentation] Biosynthesis of Natural Products Through a Fungal Molecular Genetics.2012
Author(s)
T. Nakazawa, T. Ookuma, S. Sugimoto, S. Ichinoseki, Y. Gotanda, N. Ishikawa, Y. Tsunematsu, K. Ishiuchi, H. Noguchi, K. Watanabe
Organizer
11th European Conference on Fungal Genetics
Place of Presentation
Philipps-Universitat Marburg, Germany
Related Report
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