| Project/Area Number |
23880036
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Food science
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| Research Institution | National Fisheries University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 褐藻 / アレルギー / 食品機能 / 水産化学 / 生理活性 / フロロタンニン |
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| Research Abstract |
The condensed phlorotannin from a brown alga Eisenia arborea on allergic model mouse orally administered ovalbumin (allergen) exhibited the anti-allergic effects due to the improvement of immunity balance. When the experiment of mouse ear edema was carried out, four kinds of phlorotannins exhibited anti-inflammatory effects. When the intestinal absorption of the active compound (phlorotannin) was evaluated using Caco-2 cells that are the intestinal absorption model, about 5 % of phlorotannin was permeated. And, as anti-allergic compound, a kind of phlorotannin dieckol was isolated from the lipophilic fraction of E. arborea extract.
About brown algae except for E. arborea, the extracts of Ecklonia kurome and E. stolonifera exhibited anti-allergic and anti-inflammatory effects. Moreover, a red alga Hypnea charoides was focused as minor edible seaweed, and the hot water extract of the seaweed exhibited anti-coagulant and hypocholesterolemic effects in rats.
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