Clarification of innate immune system in multiple sclerosis

Research Project

Project/Area Number	23890005
Research Category	Grant-in-Aid for Research Activity Start-up
Allocation Type	Single-year Grants
Research Field	Neurology
Research Institution	Hokkaido University
Principal Investigator	HIROTANI Makoto 北海道大学, 北海道大学病院, 助教 (60399920)
Co-Investigator(Renkei-kenkyūsha)	SASAKI Hidenao 北海道大学, 大学院・医学研究科, 教授 (80281806)
Project Period (FY)	2011 – 2012
Project Status	Completed (Fiscal Year 2012)
Budget Amount *help	¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000) Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000) Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords	神経免疫 / 多発性硬化症 / 自然免疫
Research Abstract	We aimed to examine the impact of IFN-α, which is an important adjuvant in the innate immune system, on the adaptive immune system in Multiple Sclerosis (MS). There results suggest that CpG DNA-induced decreased IFN-α production causes pro-inflammatory cytokine secretion, and either IFN-α or IFN-ss induces anti-inflammatory cytokine secretion in the adaptive immune system in MS.