Development of quantitative viability and vascular territory mapping for head and neck cancer by using magnetic resonance imaging technique

• Project/Area Number: 23890007
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Radiation science
• Research Institution: Hokkaido University
• Principal Investigator: FUJIMA Noriyuki 北海道大学, 北海道大学病院, 助教 (80431360)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000); Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 磁気共鳴画像 / 頭頸部腫瘍 / 腫瘍血流 / MRI / 画像 / 癌 / 解析学

Research Abstract

Quantitative assessment of head and neck tumor vascularity and determination of its vascular territory of each feeding artery can be accomplished by using arterial spin labeling technique. This technique was validated by FDG-PET, digital subtraction angiography, angio-CT. This technique will be useful tool for non-invasive assessment in patients with head and neck cancer who received choemoradiotherapy such as super-selective arterial infusion of cisplatin with concomitant radiotherapy.

Research Products

• [Presentation] Usefulness of Pseudo Continuous Arterial Spin Labeling for Head and Neck Squamous Cell Carcinoma (2013)
  • Author(s): Fujima N
  • Organizer: ISMRM 21st Annual Meeting
  • Place of Presentation: Salt Palace Convention Center (USA)
• [Presentation] Tumor Blood Flow Measurement by Pseudo-Continuous Arterial Spin Labeling (pCASL) in Head and Neck Cancer (2013)
  • Author(s): Fujima N
  • Organizer: Comparison to Dynamic Contrast Enhanced MRI, ECR (European Congress of Radiology)2013
  • Place of Presentation: Vienna InternationalCentre (Austria)
• [Presentation] Tumor Blood Flow Measurement by Pseudo-Continuous Arterial Spin Labeling (pCASL) in Head and Neck Cancer; Comparison to Dynamic Contrast Enhanced MRI (2013)
  • Author(s): Noriyuki Fujima
  • Organizer: ECR (European Congress of Radiology) 2013
  • Place of Presentation: Vienna International Centre (Austria)
• [Presentation] pCASLおよびIVIM-DWIを利用した頭頸部腫瘍の早期治療効果判定と予後予測因子の検討 (2012)
  • Author(s): 藤間憲幸
  • Organizer: 第40回日本磁気共鳴医学会大会
  • Place of Presentation: 国立京都国際会館(京都府)
• [Presentation] 頭頚部腫瘍へのArterial spin labelingの有用性の検討 (2011)
  • Author(s): 藤間憲幸
  • Organizer: 第124回日本医学放射線学会北日本地方会
  • Place of Presentation: アイーナいわて県民情報交流センター(岩手県)
  • Year and Date: 2011-06-17
• [Presentation] Arterial spin-labeling to determine tumor viability in head and neck cancer before and after treatment (2011)
  • Author(s): Fujima N
  • Organizer: RSNA97th Scientific Assembly and Annual Meeting
  • Place of Presentation: McCormick Place (USA)
• [Presentation] 頭頚部腫瘍に対するArterial spin labelingの有用性の検討 (2011)
  • Author(s): 藤間憲幸
  • Organizer: 第39回日本磁気共鳴医学会大会
  • Place of Presentation: リーガロイヤルホテル小倉(福岡県)
• [Presentation] 頭頚部腫瘍に対するArterial spin labelingの有用性の検討 (2011)
  • Author(s): 藤間憲幸、吉田大介、坂下智博、本間明宏、塚原亜希子、Tha Ehin Khin、財津有里、寺江聡、白土博樹
  • Organizer: 第39回 日本磁気共鳴医学会大会
  • Place of Presentation: リーガロイヤルホテル小倉(福岡)
• [Presentation] Arterial spin-labeling to detetmine tumor viability in head and neck cancer before and after treatment (2011)
  • Author(s): Fujima N, Yoshida D, Sakasbita T, Homma A, Kudo K, Tsukahara A, Terae S, Shirato H
  • Organizer: RSNA 97th Scientific Assembly and Annual Meeting
  • Place of Presentation: McCormick Place (米国)