Sialic acid binding immunoglobulin like lectin regulates osteoclast differentiation and function in destructive bone diseases
| Project/Area Number |
23890008
|
|---|
| Research Category |
Grant-in-Aid for Research Activity Start-up
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Orthopaedic surgery
|
|---|
| Research Institution | Hokkaido University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2011 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
|---|
| Keywords | 破骨細胞 / シグレック 15 / 細胞骨格 / 骨吸収 / 細胞融合 / 糖鎖 / 免疫グロブリン様受容体 / Siglec-15 / シグレック / シアル酸 / 糖鎖受容体 |
|---|
| Research Abstract |
Using genetically modified mice lacking Siglec-15 gene, we show that Siglec-15 regulates osteoclast development and bone resorption by modulating receptor activator of nuclear factor κB ligand (RANKL) signaling, in association with DNAX-activating protein 12kDa (DAP12), an adaptor protein bearing an immunoreceptor tyrosine-based activation motif (ITAM).
|
Report
(3 results)
Research Products
(6 results)
