Failure of ARE-nRNA control causes oncogenesis of oral cancer

• Project/Area Number: 23890010
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Surgical dentistry
• Research Institution: Hokkaido University
• Principal Investigator: KUROSHIMA Takeshi 北海道大学, 大学院・歯学研究科, 専門研究員 (00610669)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000); Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 口腔がん / ARE-mRNA / pp32 / pp32r1 / HuR / PP32r1

Research Abstract

In this study, we examined the mechanism of the export and stabilization of ARE-mRNA in oral cancer cells. We explored the role of pp32r1, a member of the pp32 family that has oncogenic properties, in the decay of HuR. HuR-pp32r1 complex was exported to the cytoplasm and the caspase-mediated decay of HuR was inhibited by pp32r1. We suggest that this function contributes to the oncogenic activity of pp32r1.

Research Products

• [Journal Article] Viral - mediated sta bilization of AU - rich element containing mRNA contributes to cell transformation (2011)
  • Author(s): Kuroshima T , Aoyagi M , Yasuda M , Kitamura T,他6名
  • Journal Title: Oncogene Volume: 30(26) Issue: 26 Pages: 2912-20
  • DOI: 10.1038/onc.2011.14
  • Peer Reviewed
• [Presentation] アデノウイルス感染は宿主細胞のP-Bodiesに特異的な変化をもたらす (2012)
  • Author(s): 柳川-松田彩、東野史裕、黒嶋雄志、安田元昭、北村哲也、進藤正信
  • Organizer: 第92回北海道医学大会病理分科会
  • Place of Presentation: 札幌、札幌医大
  • Year and Date: 2012-10-13
• [Presentation] アデノウイルス感染によるP-bodiesの変化はARE-mRNAの分解に影響する (2012)
  • Author(s): 柳川-松田彩、黒嶋雄志、安田元昭、北村哲也、進藤正信、東野史裕
  • Organizer: 第35回日本分子生物学会年会
  • Place of Presentation: 福岡、福岡国際会議場
• [Presentation] アデノウイルス感染がもたらす宿主細胞P-bodyの変化 (2012)
  • Author(s): 柳川-松田彩、黒嶋雄志、北村哲也、東野史裕、進藤正信
  • Organizer: 第101回日本病理学会総会
  • Place of Presentation: 東京、京王プラザホテル
• [Presentation] Stabilization of AU-rich element containing mRNA mediated by adenovirus gene product contributes to cell transformation (2011)
  • Author(s): Kuroshima T.,Yasuda M., Kitamura T., Yanagawa-Matsuda A., Shindoh M. and Higashino F
  • Organizer: IUMS 2011 (International Union of Microbiological Societies 2011Congress)
  • Place of Presentation: Sapporo, JAPAN
  • Year and Date: 2011-09-14
• [Presentation] アデノウイルス感染細胞でのRNP顆粒構造の挙動 (2011)
  • Author(s): 東野史裕、黒嶋雄志、北村哲也、柳川-松田彩、進藤正信
  • Organizer: 第63回日本細胞生物学会大会
  • Place of Presentation: 札幌、北海道大学
  • Year and Date: 2011-06-28
• [Presentation] Modulation of P bodies and stress granules in adenovirus infected cells (2011)
  • Author(s): Kuroshima T., Kitamura T.,Yanagawa-Matsuda A., Shindoh M. and Higashino F
  • Organizer: RNA 2011 (Sixteenth Annual Meeting of the RNA Society)
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 2011-06-15
• [Presentation] ARE-mRNAの安定化は細胞がん化を誘導する (2011)
  • Author(s): 黒嶋雄志
  • Organizer: 第100回日本病理学会総会
  • Place of Presentation: 横浜、パシフィコ横浜
  • Year and Date: 2011-04-28
• [Presentation] ARE-mRNAを安定化させることは細胞のがん化に寄与する (2011)
  • Author(s): 黒嶋雄志
  • Organizer: 第65回日本口腔科学会学術総会
  • Place of Presentation: 東京、タワーホール船堀
  • Year and Date: 2011-04-22
• [Remarks] 北海道大学 PRESS RELEASE （ARE-mRNA の安定化による細胞がん化を証明）
  • URL: http://www.hokudai.ac.jp/bureau/topics/press_release/110223_pr_den.pdf
• [Remarks]
  • URL: http://www.hokudai.ac.jp/bureau/topics/press_release/110223_pr_den.pdf