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Failure of ARE-nRNA control causes oncogenesis of oral cancer

Research Project

Project/Area Number 23890010
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Surgical dentistry
Research InstitutionHokkaido University

Principal Investigator

KUROSHIMA Takeshi  北海道大学, 大学院・歯学研究科, 専門研究員 (00610669)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords口腔がん / ARE-mRNA / pp32 / pp32r1 / HuR / PP32r1
Research Abstract

In this study, we examined the mechanism of the export and stabilization of ARE-mRNA in oral cancer cells. We explored the role of pp32r1, a member of the pp32 family that has oncogenic properties, in the decay of HuR. HuR-pp32r1 complex was exported to the cytoplasm and the caspase-mediated decay of HuR was inhibited by pp32r1. We suggest that this function contributes to the oncogenic activity of pp32r1.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • Research Products

    (11 results)

All 2012 2011 Other

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (8 results) Remarks (2 results)

  • [Journal Article] Viral - mediated sta bilization of AU - rich element containing mRNA contributes to cell transformation2011

    • Author(s)
      Kuroshima T , Aoyagi M , Yasuda M , Kitamura T,他6名
    • Journal Title

      Oncogene

      Volume: 30(26) Issue: 26 Pages: 2912-20

    • DOI

      10.1038/onc.2011.14

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Presentation] アデノウイルス感染は宿主細胞のP-Bodiesに特異的な変化をもたらす2012

    • Author(s)
      柳川-松田彩、東野史裕、黒嶋雄志、安田元昭、北村哲也、進藤正信
    • Organizer
      第92回北海道医学大会病理分科会
    • Place of Presentation
      札幌、札幌医大
    • Year and Date
      2012-10-13
    • Related Report
      2012 Final Research Report
  • [Presentation] アデノウイルス感染によるP-bodiesの変化はARE-mRNAの分解に影響する2012

    • Author(s)
      柳川-松田彩、黒嶋雄志、安田元昭、北村哲也、進藤正信、東野史裕
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡、福岡国際会議場
    • Related Report
      2012 Final Research Report
  • [Presentation] アデノウイルス感染がもたらす宿主細胞P-bodyの変化2012

    • Author(s)
      柳川-松田彩、黒嶋雄志、北村哲也、東野史裕、進藤正信
    • Organizer
      第101回日本病理学会総会
    • Place of Presentation
      東京、京王プラザホテル
    • Related Report
      2012 Final Research Report
  • [Presentation] Stabilization of AU-rich element containing mRNA mediated by adenovirus gene product contributes to cell transformation2011

    • Author(s)
      Kuroshima T.,Yasuda M., Kitamura T., Yanagawa-Matsuda A., Shindoh M. and Higashino F
    • Organizer
      IUMS 2011 (International Union of Microbiological Societies 2011Congress)
    • Place of Presentation
      Sapporo, JAPAN
    • Year and Date
      2011-09-14
    • Related Report
      2012 Final Research Report
  • [Presentation] アデノウイルス感染細胞でのRNP顆粒構造の挙動2011

    • Author(s)
      東野史裕、黒嶋雄志、北村哲也、柳川-松田彩、進藤正信
    • Organizer
      第63回日本細胞生物学会大会
    • Place of Presentation
      札幌、北海道大学
    • Year and Date
      2011-06-28
    • Related Report
      2012 Final Research Report
  • [Presentation] Modulation of P bodies and stress granules in adenovirus infected cells2011

    • Author(s)
      Kuroshima T., Kitamura T.,Yanagawa-Matsuda A., Shindoh M. and Higashino F
    • Organizer
      RNA 2011 (Sixteenth Annual Meeting of the RNA Society)
    • Place of Presentation
      Kyoto, Japan
    • Year and Date
      2011-06-15
    • Related Report
      2012 Final Research Report
  • [Presentation] ARE-mRNAの安定化は細胞がん化を誘導する2011

    • Author(s)
      黒嶋雄志
    • Organizer
      第100回日本病理学会総会
    • Place of Presentation
      横浜、パシフィコ横浜
    • Year and Date
      2011-04-28
    • Related Report
      2012 Final Research Report
  • [Presentation] ARE-mRNAを安定化させることは細胞のがん化に寄与する2011

    • Author(s)
      黒嶋雄志
    • Organizer
      第65回日本口腔科学会学術総会
    • Place of Presentation
      東京、タワーホール船堀
    • Year and Date
      2011-04-22
    • Related Report
      2012 Final Research Report
  • [Remarks] 北海道大学 PRESS RELEASE (ARE-mRNA の安定化による細胞がん化を証明)

    • URL

      http://www.hokudai.ac.jp/bureau/topics/press_release/110223_pr_den.pdf

    • Related Report
      2012 Annual Research Report
  • [Remarks]

    • URL

      http://www.hokudai.ac.jp/bureau/topics/press_release/110223_pr_den.pdf

    • Related Report
      2011 Annual Research Report

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Published: 2011-09-05   Modified: 2019-07-29  

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