Exaggerated lymphangiogenesis and remodeled blood vessels in a mouse model and human patients of aspiration pneumonia
| Project/Area Number |
23890018
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 誤嚥性肺炎 / リンパ管新生 / 血管のリモデリング / マウスモデル / 慢性炎症 / 動物実験モデル |
|---|
| Research Abstract |
Previous studies did not show chronic inflammation or vascular changes in aspiration pneumonia or its animal models. We established a mouse model of aspiration pneumonia, and showed chronic inflammation, blood vessel remodeling, and lymphangiogenesis in the model and in patients.
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Report
(3 results)
Research Products
(12 results)
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[Journal Article] Royal jelly prevents the progression of sarcopenia in aged mice in vivo and in vitro2013
Author(s)
Kaijun Niu, Hui Guo, Yinting Guo, Satoru Ebihara, Masanori Asada, Takashi Ohrui, Katsutoshi Furukawa, Masakazu Ichinose,Kazuhiko Yanai, Yukitsuka Kudo, Hiroyuki Arai, Tatsuma Okazaki, and Ryoichi Nagatomi
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Journal Title
Journal of Gerontology: Biological Sciences
Volume: (掲載確定)
Issue: 12
Pages: 1482-1492
DOI
Related Report
Peer Reviewed
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[Journal Article] Adiponectin Pathway Attenuates Malignant Mesothelioma Cell Growth2012
Author(s)
Niu K, Asada M, Okazaki T, Yamanda S, Ebihara T, Guo H, Zhang D, Nagatomi R, Arai H, Kohzuki M, Ebihara S.
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Journal Title
Am J Respir Cell Mol Biol
Volume: 46
Pages: 515-23
Related Report
Peer Reviewed
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