Exaggerated lymphangiogenesis and remodeled blood vessels in a mouse model and human patients of aspiration pneumonia

• Project/Area Number: 23890018
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Respiratory organ internal medicine
• Research Institution: Tohoku University
• Principal Investigator: OKAZAKI Tatsuma 東北大学, 病院, 助教 (40396479)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000); Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 誤嚥性肺炎 / リンパ管新生 / 血管のリモデリング / マウスモデル / 慢性炎症 / 動物実験モデル

Research Abstract

Previous studies did not show chronic inflammation or vascular changes in aspiration pneumonia or its animal models. We established a mouse model of aspiration pneumonia, and showed chronic inflammation, blood vessel remodeling, and lymphangiogenesis in the model and in patients.

Research Products

• [Journal Article] Royal jelly prevents the progression of sarcopenia in aged mice in vivo and in vitro (2013)
  • Author(s): Kaijun Niu, Hui Guo, Yinting Guo, Satoru Ebihara, Masanori Asada, Takashi Ohrui, Katsutoshi Furukawa, Masakazu Ichinose,Kazuhiko Yanai, Yukitsuka Kudo, Hiroyuki Arai, Tatsuma Okazaki, and Ryoichi Nagatomi
  • Journal Title: Journal of Gerontology: Biological Sciences Volume: (掲載確定) Issue: 12 Pages: 1482-1492
  • DOI: 10.1093/gerona/glt041
  • Peer Reviewed
• [Journal Article] Royal jelly prevents the progression of sarcopenia in aged mice in vivo and in vitro (2013)
  • Author(s): Kaijun Niu
  • Journal Title: Journal of Gerontology: Biological Sciences Volume: 掲載確定
  • Peer Reviewed
• [Journal Article] Adiponectin Pathway Attenuates Malignant Mesothelioma Cell Growth (2012)
  • Author(s): Niu K, Asada M, Okazaki T, Yamanda S, Ebihara T, Guo H, Zhang D, Nagatomi R, Arai H, Kohzuki M, Ebihara S.
  • Journal Title: Am J Respir Cell Mol Biol Volume: 46 Pages: 515-23
  • Peer Reviewed
• [Journal Article] Adiponectin Pathway Attenuates Malignant Mesothelioma Cell Growth (2012)
  • Author(s): 岡崎達馬, 他10名
  • Journal Title: Am J Respir Cell Mol Biol Volume: 46(4) Pages: 515-523
  • Peer Reviewed
• [Journal Article] Impact of physical activity and performance on medical care costs among the Japanese elderly (2011)
  • Author(s): 岡崎達馬, 他14名
  • Journal Title: Geriatr Gerontol Int Volume: 11(2) Issue: 2 Pages: 157-165
  • DOI: 10.1111/j.1447-0594.2010.00651.x
  • NAID: 10029333371
  • Peer Reviewed
• [Presentation] 正和新規通常型誤嚥性肺炎のマウスモデルの確立とその脈管系の解析 (2013)
  • Author(s): 岡崎達馬、海老原覚、海老原孝枝、一ノ瀬
  • Organizer: 日本老年学会
  • Place of Presentation: 大阪
  • Year and Date: 2013-06-05
• [Presentation] Exaggerated lymphangiogenesis and remodeled blood vessels in a mouse model and human patients of aspiration pneumonia (2013)
  • Author(s): Tatsuma Okazaki, Mayumi Nihei, Satoru Ebihara, Makoto Kobayashi, Kaijun Niu, Mutsuo Yamaya, Takae Ebihara, and Masakazu Ichinose
  • Organizer: American thoracic society
  • Place of Presentation: フィラデルフィア米国
  • Year and Date: 2013-05-22
• [Presentation] 誤嚥性肺炎の新規動物モデルの確立と革新的治療法の探索 (2013)
  • Author(s): 二瓶真由美、岡崎達馬、小林誠、菊地利明、海老原覚、一ノ瀬正和
  • Organizer: 日本呼吸器学会
  • Place of Presentation: 東京
  • Year and Date: 2013-04-20
• [Presentation] Effects of Muscle-Specific Inhibition Of The NF-kB Pathway On Diaphragmatic Function In Murine Sepsis (2012)
  • Author(s): Tatsuma Okazaki, Basil Petrof
  • Organizer: American thoracic society
  • Place of Presentation: サンフランシスコ米国
  • Year and Date: 2012-05-22
• [Presentation] 誤嚥性肺炎の新規動物モデルの確立と革新的治療法の探索
  • Author(s): 二瓶 真由美
  • Organizer: 日本呼吸器学会
  • Place of Presentation: 東京
• [Presentation] Exaggerated lymphangiogenesis and remodeled blood vessels in a mouse model and human patients of aspiration pneumonia
  • Author(s): Makoto Kobayashi
  • Organizer: American thoracic society
  • Place of Presentation: フィラデルフィア 米国
• [Presentation] 新規通常型誤嚥性肺炎のマウスモデルの確立とその脈管系の解析
  • Author(s): 岡崎 達馬
  • Organizer: 日本老年学会
  • Place of Presentation: 大阪