The analysis of molecular mechanisms of the inflammatory macrophage migration by using a small molecule inhibitor to plasminogen activator inhibitor 1.
| Project/Area Number |
23890019
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Endocrinology
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 薬理学 / 免疫学 / 炎症 / マクロファージ / PAI-1 / 免疫細胞遊走 / 抗炎症 / 線溶系 |
|---|
| Research Abstract |
Our findings demonstrated that a small molecule PAI-1 inhibitor represents a novel class of anti-inflammatory agents targeting MФ migration by the inhibition of the interaction of PAI-1 with low-density lipoprotein receptor-related protein.
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Report
(3 results)
Research Products
(15 results)
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[Journal Article] A smoll molecule inhibitor to plasminogen activator inhibitor 1 inhibits macrophage migration.2013
Author(s)
Ichimura A, Matsumoto S, Suzuki S, Dan T, Yamaki S, Sato Y, Kiyomoto H, Ishii N, Okada K, Matsuo O, Hou FF, Vaughan DE, van Ypersele de Strihou S, Miyata T.
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Journal Title
Arterioscler Thromb Vasc Biol.
Volume: 33
Issue: 5
Pages: 935-942
DOI
Related Report
Peer Reviewed
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