| Project/Area Number |
23890022
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Orthodontic/Pediatric dentistry
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| Research Institution | Tohoku University |
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Principal Investigator |
ARAKAKI Makiko 東北大学, 大学院・歯学研究科, 助教 (80610675)
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| Project Period (FY) |
2011 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | iPS細胞 / エナメル芽細胞 / 歯 / 再生 / 歯原性上皮細胞 / 人工多能性幹細胞（iPS細胞） / アメロブラスチン / 歯の再生 / 人工多能性幹細胞(iPS細胞) |
|---|
| Research Abstract |
iPS cells are capable to be induced to ameloblasts when iPS cells were cultured with ameloblastin (Ambn) high expression dental epithelial cell line SF2-24, or cultured in the presence of conditioned medium (CM) of SF2-24 culture supernatant. Additionally, it is indicated that soluble factors such as Ambn, NT-4 and BMP, secreted from SF2 cells to culture medium, perform an important role for differentiation iPS cellsinto ameloblasts.
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